Occupational risks for male fertility: an analysis of patients attending a tertiary referral centre
Occupational risks for male fertility: an analysis of patients attending a tertiary referral centre
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DOI：
10.1046/j.1365-2605.2001.00304.x
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发表时间：
2001-12-01
影响因子：
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通讯作者：
Nieschlag, E
中科院分区：
文献类型：
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作者：
Kenkel, S;Rolf, C;Nieschlag, E
环境和职业对男性生育力的影响仍在争论之中。我们调查了某些职业是否可能是过度或不足的代表性之间的男性参加我们的不孕不育诊所相对于该地区的整个人口。本文对明斯特地区2054例男性不育症的诊断和精液参数进行了回顾性分析。患者被分为29个职业组。将每个群体的相对规模与明斯特区的总人口规模进行比较。与一般人口相比，农民的比例过高。与整个不育男性组相比，农民和油漆工/油漆工显示出显著更高比例的精子计数减少[比值比（OR）：2.13和2.17，95%置信区间：1.18-3.88和1.02-4.65]和严重减少的精子浓度;此外，与其他职业群体相比，（OR：2.76和2.84; CI：1.12-6.75和1.27-6.34）。金属工人/焊工精子活力降低的患者比例显着较高（OR：5.99; CI：1.38-26.00）。油漆工/吸血鬼的精液参数相对较差可能是由于暴露于毒素所致。这也可能适用于农民（化肥，除草剂）;然而，睾丸发育不良率的升高表明产前发育期间暴露的影响或遗传原因。金属工人/焊工的发现可能是因为工作场所的热量或毒素。这项研究表明，某些职业与男性不育症有优先关系。
The impact of environment and occupation on male fertility is still under debate. We investigated whether certain occupations may be over- or under-represented among men attending our infertility clinic in relation to the entire population of the area. Diagnoses and semen parameters of 2054 infertile men from the district of Munster were analysed retrospectively. The patients were categorized into 29 occupational groups. The relative size of each group was compared with that of the entire population in the district of Munster. Farmers were over-represented compared with the general population. Farmers and painters/varnishers showed a significantly higher proportion of reduced sperm counts [odds ratios (OR): 2.13 and 2.17, 95% confidence intervals: 1.18-3.88 and 1.02-4.65] and severely reduced sperm concentrations compared with the entire group of infertile men; in addition, significantly more farmers presented with a history of maldescended testes than other occupational groups (OR: 2.76 and 2.84; Cl: 1.12-6.75 and 1.27-6.34). Metal workers/welders formed significantly higher proportions of patients with reduced sperm motility (OR: 5.99; Cl: 1.38-26.00). The relatively poor semen parameters of the painters/vamishers could be caused by exposure to toxins. This may also apply to the farmers (fertilizers, herbicides); however, the elevated rate of maldescended testes suggests an effect of exposure during prenatal development or a genetic cause. The findings for metal workers/welders may be because of heat or toxins at the workplace. The study demonstrates that certain occupations are preferentially associated with male infertility.