A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides
A new class of easily activated palladium precatalysts for facile C-N cross-coupling reactions and the low temperature oxidative addition of aryl chlorides
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DOI：
10.1021/ja801137k
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发表时间：
2008-05-28
影响因子：
15
通讯作者：
Buchwald, Stephen L.
中科院分区：
文献类型：
--
作者：
Biscoe, Mark R.;Fors, Brett P.;Buchwald, Stephen L.
描述了一类带有联芳基膦配体的新型单组分钯预催化剂。这些预催化剂对空气和热稳定，在室温或低于室温的正常反应条件下很容易活化，并确保形成氧化加成所需的高活性单配位 Pd(0) 络合物。探索了在 C-N 交叉偶联反应中使用这些预催化剂作为 LPd(0) 的便捷来源。这项研究所证明的反应活性在钯化学中是前所未有的。
A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally stable, are easily activated under normal reaction conditions at or below room temperature and ensure the formation of the highly active monoligated Pd(0) complex necessary for oxidative addition. The use of these precatalysts as a convenient source of LPd(0) in C-N cross-coupling reactions is explored. The reactivity that is demonstrated in this study is unprecedented in palladium chemistry.