T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity
T-cell subsets in delayed-type hypersensitivity, protection, and granuloma formation in primary and secondary Listeria infection in mice: superior role of Lyt-2+ cells in acquired immunity
复制标题
小鼠原发性和继发性李斯特菌感染中迟发型超敏反应、保护和肉芽肿形成中的 T 细胞亚群：Lyt-2 细胞在获得性免疫中的卓越作用
作者：
Martin E. A. Mielke;Stefan Ehlers;Helmut Hahn
在用 Thy-1.2、L3T4 和 Lyt-2 T 细胞标记物特异性的大鼠单克隆抗体 (MAb) 治疗的小鼠中研究了对单核细胞增生李斯特菌的免疫。研究了三种特征性 T 细胞介导的现象。在用抗Thy-1.2或抗L3T4 MAb治疗的小鼠中，对李斯特菌抗原的迟发型超敏反应（DTH）完全消失，而抗Lyt-2 MAb治疗没有效果，无论是否在诱导或DTH表达期间给予MAb。另一方面，仅通过应用抗Thy-1.2 MAb 或抗Lyt-2 MAb 来抑制细菌从受感染动物脾脏中的消除。在用通常致死剂量的李斯特菌对免疫小鼠进行二次感染时，这一点最为令人印象深刻。在这种情况下，用抗Lyt-2 MAb治疗足以完全消除免疫记忆，而抗L3T4 MAb对抗菌保护仅具有边际效应。然而，抗L3T4 MAb和抗Lyt-2 MAb的应用均抑制了免疫小鼠肝脏中单核细胞灶的加速发展。结论是，在鼠李斯特菌病中，DTH 和对再感染的获得性免疫是分离的现象。尽管 DTH 是 L3T4+ T 淋巴细胞的功能，但 Lyt-2+ T 细胞对于表达对单核细胞增生李斯特菌的获得性抗性是必要且充分的。不同 T 细胞亚群在肉芽肿形成中的作用值得进一步研究。
Immunity to Listeria monocytogenes was studied in mice treated with rat monoclonal antibodies (MAbs) specific for the Thy-1.2, L3T4, and Lyt-2 T-cell markers. Three characteristic T-cell-mediated phenomena were investigated. Delayed-type hypersensitivity (DTH) to listerial antigen was totally abolished in mice treated with anti-Thy-1.2 or anti-L3T4 MAbs, whereas anti-Lyt-2 MAb treatment had no effect, regardless of whether the MAb was given during the induction or the expression of DTH. On the other hand, the elimination of bacteria from the spleens of infected animals was inhibited only by the application of either anti-Thy-1.2 MAb or anti-Lyt-2 MAb. This could be shown most impressively during the secondary infection of immune mice with a normally lethal dose of listeriae. In this situation, treatment with anti-Lyt-2 MAb sufficed to completely abolish immunologic memory, whereas anti-L3T4 MAb had only a marginal effect on antibacterial protection. However, the accelerated development of mononuclear cell foci in the livers of immune mice was inhibited by the application of both anti-L3T4 MAb and anti-Lyt-2 MAb. It is concluded that in murine listeriosis, DTH and acquired immunity to reinfection are dissociable phenomena. Although DTH is a function of L3T4+ T lymphocytes, Lyt-2+ T cells are necessary and sufficient for the expression of acquired resistance to L. monocytogenes. The roles of the different T-cell subsets in granuloma formation warrant further investigation.
T 细胞合作介导对单核细胞增生李斯特氏菌的获得性抗性。
影响因子：
6.4
作者：
Chen-Woan,M;Sajewski,DH;McGregor,DD
通讯作者：
McGregor,DD
对单核细胞增生李斯特氏菌的免疫力过继转移。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bishop,DK;Hinrichs,DJ
通讯作者：
Hinrichs,DJ