Fat cell turnover in humans
Fat cell turnover in humans
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DOI：
10.1016/j.bbrc.2010.02.165
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发表时间：
2010-05-21
影响因子：
3.1
通讯作者：
Spalding, Kirsty L.
中科院分区：
文献类型：
--
作者：
Arner, Peter;Spalding, Kirsty L.
肥胖症是一种身体脂肪过多，以致影响健康的情况。由于与肥胖症有关的心血管和代谢紊乱，以及大多数国家今天面临的肥胖症流行，发达国家的预期寿命可能在近代历史上首次开始下降。其他病症，如神经性厌食症和恶病质，其特征在于低于正常水平的脂肪组织，并且与肥胖症一样导致发病率和死亡率。鉴于这些疾病的显著个人和经济成本及其在社会中的日益普遍，因此，了解决定脂肪量的因素是最重要的，并可能导致对这些疾病的有效治疗和/或干预。脂肪量可以通过两种方式调节。预先存在的脂肪细胞的脂质填充可以被改变，并且脂肪细胞的数量可以通过新脂肪细胞的产生或旧脂肪细胞的死亡（即脂肪细胞更新）而改变。这篇综述总结了什么是已知的脂肪细胞周转在人类和潜在的临床意义。(C)2010年爱思唯尔公司All rights reserved.
Obesity is a condition where excess body fat accumulates to such an extent that one's health may be affected. Owing to the cardiovascular and metabolic disorders associated with obesity, and the epidemic of obesity facing most countries today, life expectancy in the developed world may start to decrease for the first time in recent history. Other conditions, such as anorexia nervosa and cachexia, are characterised by subnormal levels of adipose tissue and as with obesity lead to morbidity and mortality. Given the significant personal and economic costs of these conditions and their increasing prevalence in society, understanding the factors that determine the fat mass is therefore of prime interest and may lead to effective treatments and/or interventions for these disorders. Fat mass can be regulated in two ways. The lipid filling of pre-existing fat cells could be altered and the number of fat cells could be changed by the generation of new fat cells or the dying of old ones (i.e. adipocyte turnover). This review summarizes what is known about fat cell turnover in humans and the potential clinical implications. (C) 2010 Elsevier Inc. All rights reserved.