Transcriptional Errors in Human Immunodeficiency Virus Type 1 Generate Targets for T-Cell Responses
Transcriptional Errors in Human Immunodeficiency Virus Type 1 Generate Targets for T-Cell Responses
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DOI：
10.1128/cvi.00410-08
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发表时间：
2009-09-01
影响因子：
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通讯作者：
Nixon, Douglas F.
中科院分区：
文献类型：
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作者：
Garrison, Keith E.;Champiat, Stephane;Nixon, Douglas F.
我们测量了T细胞对人类免疫缺陷病毒1型（HIV-1）隐藏表位的反应，这些表位由病毒基因组中通常不翻译成病毒蛋白的区域编码。在HIV-1感染者中检测到T细胞对隐藏表位和HIV-1病毒蛋白Rev和达特正常剪接区的应答。
We measured T-cell responses to human immunodeficiency virus type 1 (HIV-1) cryptic epitopes encoded by regions of the viral genome not normally translated into viral proteins. T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects.