Chemotherapy of germ cell tumors of the testis. I. Induction of remissions with vinblastine, actinomycin D, and bleomycin
Chemotherapy of germ cell tumors of the testis. I. Induction of remissions with vinblastine, actinomycin D, and bleomycin
复制标题
睾丸生殖细胞肿瘤的化疗。
作者：
R. Wittes;A. Yagoda;Olga Silvay;G. Magill;W. Whitmore;I. Krakoff;R. Golbey
患有播散性睾丸癌的患者接受了长春花碱、放线菌素 D 和博来霉素的联合治疗，试图诱导缓解。在接受该方案初步充分试验的 47 名患者中，34% 达到完全或部分缓解；在 18 名既往未接受非手术治疗或仅接受放线菌素 D 治疗的患者中，缓解率为 61%。与无反应者或部分反应者相比，获得完全反应状态的人的寿命显着延长。所有组织学类别均出现缓解，且与试验开始时患者的体能状态、治疗第一个月的药物总剂量或药物产生的血液毒性程度无关。有反应者的口腔炎发病率高于无反应者。
Patients with disseminated testicular carcinoma were treated with the combination of vinblastine, actinomycin D, and bleomycin in an attempt to induce remission. Of 47 patients receiving an initial adequate trial of this regimen, 34% achieved a complete or partial remission; in the 18 patients with either no prior nonsurgical treatment or treatment with actinomycin D alone, the response rate was 61%. Those who attained complete response status enjoyed significant prolongation of life compared with the nonresponders or partial responders. Responses were seen in all histologic categories and were not related to the performance status of the patient at the start of the trial, to the total dose of drug in the first month of therapy, or the extent of hematologic toxicity produced by the drugs. Responders had a higher incidence of stomatitis than nonresponders.