A familial t(9;13) balanced translocation associated with recurrent abortion. Repository identification No. GM2492.
A familial t(9;13) balanced translocation associated with recurrent abortion. Repository identification No. GM2492.
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与复发性流产相关的家族性 t(9;13) 平衡易位。
DOI：
10.1159/000131497
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Coriell,LL
中科院分区：
文献类型：
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作者：
Serra,A;Ricci,R;Aronson,MM;Mulivor,RA;Greene,AE;Coriell,LL
该成纤维细胞培养物由一名36岁男性的皮肤活检建立。他的妻子（46岁，XX）有四次妊娠，均在妊娠早期自然流产。第五次怀孕导致一个明显健康的男婴。经胰蛋白酶-Giemsa显带，核型描述为46，XY，t（9; 13）（9 qter-9 p22或p23：：13 q 14或q2 l-~ 13 qter; I3 pter-~ 13 ql 4或q21：：9 p22或p23- 9 pter）（图1）。除上述个体外，先证者父亲和新生儿外周血白细胞的核型显示相同的易位，
This fibroblast culture was established from a skin biopsy of a 36-year-old male. He was referred for chromosome analysis because his wife (46, XX) had four conse cutive conceptions ending in first-trimester spontaneous abortions. A fifth pregnancy resulted in an apparently healthy baby boy. The karyotype is described as 46, XY, t (9; 13)(9qter—9p22 or p23:: 13q 14 or q2l-~ 13qter; I3pter-~ 13ql4 or q21:: 9p22 or p23—9pter) by trypsin-Giemsa banding (fig. 1). In addition to the above individual, karyotypes prepared from peripheral blood leukocytes of the proband's father and new born son demonstrated the same transloca-