Circuits controlling vertebrate locomotion: moving in a new direction.

Circuits controlling vertebrate locomotion: moving in a new direction.
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DOI:
10.1038/nrn2608
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发表时间:
2009-07
影响因子:
34.7
通讯作者:
Goulding, Martyn
Goulding, Martyn
中科院分区:
医学1区
文献类型:
--
作者:
Goulding, Martyn

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神经生物学家长期以来一直试图了解神经系统中的回路是如何组织的,并产生特定行为背后的精确神经输出。脊髓中控制运动的运动回路通常被称为中枢模式生成器(CPG)网络,它提供了一个实验上易于处理的模型系统,用于研究中等复杂的神经元群如何产生选择的运动行为。新型分子遗传学技术的出现,加上我们对脊髓发育知识的最新进展,意味着我们现在可以全面了解运动回路的组织和运作方式。
Neurobiologists have long sought to understand how circuits in the nervous system are organized and generate the precise neural outputs that underlie particular behaviors. The motor circuits in the spinal cord that control locomotion and are commonly referred to as central pattern generator (CPG) networks, provide an experimentally tractable model system for investigating how moderately complex ensembles of neurons generate select motor behaviors. The advent of novel molecular genetic techniques coupled with recent advances in our knowledge of spinal cord development means that a comprehensive understanding of how the motor circuitry is organized and operates may now be within our grasp.
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