Relations between in-treatment and follow-up abstinence among cocaine-dependent homeless persons in three clinical trials.
Relations between in-treatment and follow-up abstinence among cocaine-dependent homeless persons in three clinical trials.
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三项临床试验中可卡因依赖的无家可归者治疗中和后续戒断之间的关系。
DOI：
10.1037/a0015296
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发表时间：
2009
影响因子：
2.3
通讯作者：
Kertesz,Stefan
中科院分区：
文献类型：
--
作者：
Vuchinich,Rudy;Wallace,Dennis;Milby,JesseB;Schumacher,JosephE;Mennemeyer,Stephen;Kertesz,Stefan
对可卡因依赖门诊患者的临床试验发现，治疗中和随访戒断之间存在很强的相关性，这种关系的强度在不同治疗条件下是恒定的，在产生戒断方面具有不同的疗效。作者对3项临床试验的数据进行了二次分析，以确定这种关系是否适用于可卡因依赖的无家可归者。3项试验（总N= 543）在无家可归者的社区卫生保健机构进行。3项试验中的7个治疗组为日间治疗、戒断相关住房和职业培训的组合。药物使用通过尿液毒理学检测进行测量。无论分析中是否包括缺失的12个月数据，治疗期间连续戒断周数与12个月随访时的戒断密切相关。治疗组在产生禁欲方面的疗效不同，但治疗中和随访禁欲之间的关系在治疗组之间没有差异。这些结果复制了早期关于这些关系的报告，并将其扩展到无家可归者群体。治疗组间在治疗-随访禁欲关系方面缺乏差异意味着该关系独立于产生组间禁欲差异的治疗特定干预成分。（PsycINFO数据库记录（c）2019阿帕，保留所有权利）
Clinical trials with cocaine-dependent outpatients have found a strong relation between in-treatment and follow-up abstinence, and the strength of this relation is constant across treatment conditions with variable efficacy in generating abstinence. The authors conducted secondary analyses of data from 3 clinical trials to determine whether this relation generalizes to cocaine-dependent homeless persons. The 3 trials (total N= 543) were conducted in a community health care facility for homeless people. The 7 treatment arms across the 3 trials were combinations of day treatment, abstinence-contingent housing, and vocational training. Drug use was measured with urine toxicology testing. Consecutive weeks of abstinence during treatment were strongly related to abstinence at the 12-month follow-up, whether or not missing 12-month data were included in the analysis. The treatment arms differed in their efficacy in generating abstinence, but the relation between in-treatment and follow-up abstinence did not differ across treatment arms. These results replicate earlier reports of these relations and extend them to a population of homeless people. The lack of differences between treatment arms in the in-treatment–follow-up abstinence relation implies that that relation is independent of the treatment-specific intervention components that generate group differences in abstinence.(PsycINFO Database Record (c) 2019 APA, all rights reserved)