The characterization of tumor apoptosis after experimental radiosurgery
The characterization of tumor apoptosis after experimental radiosurgery
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DOI：
10.1159/000084475
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发表时间：
2005-01-01
影响因子：
1.7
通讯作者：
Kondziolka, D
中科院分区：
文献类型：
--
作者：
Witham, TF;Okada, H;Kondziolka, D
我们试图评估放射外科手术是否会在实验性神经胶质瘤模型中诱导细胞凋亡，并阐明这种放射生物学现象的时间进程。 Fischer 344 只患有颅内 9L 神经胶质肉瘤的大鼠接受了放射外科手术 (n = 42) 或不接受放射外科手术 (n = 45)。治疗后3、6、12、24、48、72小时和1或2周处死动物，并通过特异性染色评估原位肿瘤细胞凋亡。值得注意的是，在放射外科治疗后的 6、24 和 48 小时时间点，经放射外科治疗的动物相对于对照组的肿瘤细胞凋亡在统计学上更高。放射外科以时间依赖性方式诱导大鼠颅内 9L 胶质肉瘤细胞凋亡。这种放射生物学现象的时间过程从放射外科手术后约 6 小时开始，持续至 48 小时，并在 72 小时开始下降。版权所有 (C) 2005 S. Karger AG，巴塞尔。
We sought to evaluate whether radiosurgery induces apoptosis in an experimental glioma model and to elucidate the time course of this radiobiologic phenomenon. Fischer 344 rats harboring established intracranial 9L gliosarcomas underwent radiosurgery ( n = 42) or no radiosurgery ( n = 45). Animals were sacrificed at 3, 6, 12, 24, 48, 72 h, and 1 or 2 weeks after treatment and in situ tumor apoptosis was assessed by specific staining. Tumor apoptosis was noted to be statistically higher in radiosurgery-treated animals relative to controls at the 6-, 24-, and 48-hour time points following radiosurgery. Radiosurgery induces apoptosis in the rat intracranial 9L gliosarcoma in a time-dependent fashion. The time course of this radiobiologic phenomenon begins at approximately 6 h following radiosurgery, continues up to 48 h, and begins to decline by 72 h. Copyright (C) 2005 S. Karger AG, Basel.