Impact of shear rate modulation on vascular function in humans.
Impact of shear rate modulation on vascular function in humans.
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DOI：
10.1161/hypertensionaha.109.134361
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Green DJ
中科院分区：
文献类型：
--
作者：
Tinken TM;Thijssen DH;Hopkins N;Black MA;Dawson EA;Minson CT;Newcomer SC;Laughlin MH;Cable NT;Green DJ
剪切应力是人体运动和训练时动脉适应性的重要刺激因素。我们最近观察到显着的反向动脉血流和剪切运动过程中，不同的顺行/逆行模式的剪切和流量，以响应不同类型的运动。本研究的目的是同时检查流量介导的扩张（FMD），主要是一氧化氮介导的血管舒张反应，在健康的年轻男性的肱动脉前和后30分钟的干预措施，包括双侧前臂加热，卧腿骑自行车和双侧握力练习。在每次干预期间，将充气至60 mmHg的袖带放置在一只手臂上，以单侧操纵剪切速率刺激。在无袖带组中，每种干预措施的前向性血流和剪切力增加相似（ANOVA; P<0.001，干预措施之间无相互作用; P=0.71）。基线FMD（4.6，6.9和6.7%）在加热，手柄和骑自行车时增加相似（8.1，10.4和8.9%，ANOVA; P<0.001，无相互作用; 0.89）。相比之下，在所有条件下，套囊臂的顺行剪切率均低于非套囊臂（P<0.05），并且该臂的FMD增加被消除（4.7、6.7和6.1%）（双因素ANOVA：所有条件相互作用P<0.05）。这些结果表明，在人类的血管内皮舒张功能的顺行剪切率的幅度的差异，这可能与不同的运动干预对血管适应的影响在人类的发现。
Shear stress is an important stimulus to arterial adaptation in response to exercise and training in humans. We recently observed significant reverse arterial flow and shear during exercise and different antegrade/retrograde patterns of shear and flow in response to different types of exercise. The purpose of this study was to simultaneously examine flow mediated dilation (FMD), a largely nitric oxide mediated vasodilator response, in both brachial arteries of healthy young men before and after 30-minute interventions consisting of bilateral forearm heating, recumbent leg cycling and bilateral handgrip exercise. During each intervention, a cuff inflated to 60mmHg was placed on one arm to unilaterally manipulate the shear rate stimulus. In the non-cuffed arm, antegrade flow and shear increased similarly in response to each intervention (ANOVA; P<0.001, no interaction between interventions; P=0.71). Baseline FMD (4.6, 6.9 and 6.7%) increased similarly in response to heating, handgrip and cycling (8.1, 10.4 and 8.9%, ANOVA; P<0.001, no interaction; 0.89). In contrast, cuffed arm antegrade shear rate was lower than in the non-cuffed arm for all conditions (P<0.05) and the increase in FMD was abolished in this arm (4.7, 6.7 and 6.1%) (2-way ANOVA: all conditions interacted P<0.05). These results suggest that differences in the magnitude of antegrade shear rate transduce differences in endothelial vasodilator function in humans, a finding which may have relevance for the impact of different exercise interventions on vascular adaptation in humans.