LEUKOCYTE RESPONSE DURING VIRAL RESPIRATORY ILLNESS IN MAN
LEUKOCYTE RESPONSE DURING VIRAL RESPIRATORY ILLNESS IN MAN
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DOI：
10.7326/0003-4819-64-3-521
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发表时间：
1966-01-01
影响因子：
39.2
通讯作者：
COUCH, RB
中科院分区：
文献类型：
--
作者：
DOUGLAS, RG;ALFORD, RH;COUCH, RB
对接种了四种呼吸道病毒之一的 113 名正常成年男性志愿者进行了连续外周血白细胞计数。在患病的志愿者中观察到白细胞计数的变化，但在未患病的感染者中观察到白细胞计数的变化。接种鼻病毒 NTH 1734 后出现普通感冒，并与循环中性粒细胞中度增加相关。在流感病毒 A2/Bethesda/10/63 患病期间，中性粒细胞也出现类似的增加，并且这种变化伴随着淋巴细胞的减少。考克斯萨基病毒 A-21 疾病也与中性粒细胞升高和淋巴细胞下降有关。此外，中性粒细胞减少发生较晚。中度严重的 4 型腺病毒疾病与中度中性粒细胞减少症相关。在病情较严重的志愿者中，淋巴细胞在患病前出现了升高，而在病情较轻的志愿者中，无论接种了何种病毒，都没有出现淋巴细胞升高。因此，不同呼吸道病毒引起的疾病与不同的白细胞变化相关，尽管这些病毒引起的疾病是相似的。发病时经常出现轻度白细胞增多伴中性粒细胞增多，表明这一发现无助于区分病毒性和细菌性呼吸道疾病。然而，疾病后期发生的中性粒细胞减少症导致的白细胞减少表明该疾病本质上是病毒性的，而疾病后期发生的白细胞增多则表明非病毒起源的呼吸道疾病。
Serial peripheral leukocyte counts were performed in 113 normal adult male volunteers who were inoculated with one of four respiratory viruses. Changes in leukocyte counts were observed in ill volunteers, but not in those infected who were not ill. Common colds developed after inoculation with rhinovirus NTH 1734 and were associated with moderate increase in circulating neutrophils. Similar neutrophil increase occurred during illness with influenza virus A2/Bethesda/10/63 and this change was accompanied by a decrease in lymphocytes. Cox-sackievirus A-21 illness was also associated with neutrophil rise and lymphocyte fall. In addition, neutrophil decrease occurred later. Adeno-virus type 4 illness which was moderately severe was associated with moderate neutropenia. A rise in lymphocytes occurred prior to illness in more severely ill volunteers, a rise not seen in less severely ill volunteers, regardless of virus inoculum. Thus, illness with different respiratory viruses is associated with different white blood cell changes, although the illnesses caused by these agents are similar. The frequent occurrence of mild leukocytosis with neutrophilia at the onset of illness suggests that this finding is not helpful in differentiating viral from bacterial respiratory illnesses. Leukopenia due to neutropenia occurring later in illness would, however, suggest that the illness was viral in nature, whereas leukocytosis occurring later in illness would suggest a respiratory illness of a non-viral origin.