Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice.
Arachidonic acid prevents fatty liver induced by conjugated linoleic acid in mice.
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DOI：
10.1017/s0007114508091253
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发表时间：
2009-05
期刊：
影响因子：
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通讯作者：
D. Oikawa;S. Tsuyama;Yoriko Akimoto;Yurika Mizobe;M. Furuse
中科院分区：
文献类型：
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作者：
D. Oikawa;S. Tsuyama;Yoriko Akimoto;Yurika Mizobe;M. Furuse
共轭亚油酸（CLA）具有抗肥胖作用，但可诱导小鼠脂肪肝。本研究探讨是否共同管理的花生四烯酸（ARA）减弱脂肪堆积在小鼠肝脏由共轭亚油酸诱导。雄性小鼠（8周龄）给予不添加膳食脂肪（对照）、3%亚油酸（LA）、3%CLA、3%CLA +1%ARA或3%CLA +2%ARA的饮食4周。与对照组或LA组相比，ARA治疗组的肾周脂肪重量与单独使用CLA的情况相似。CLA组的血浆TAG浓度显著高于CLA+ARA组，而血浆胆固醇和NEFA浓度在各组之间没有变化。与内脏脂肪相比，CLA组的肝脏重量显著高于对照组或LA组，ARA可减弱CLA的作用。TAG和胆固醇显着积累在肝脏与饮食CLA，而共同管理与ARA，在任何浓度下，抑制CLA诱导的脂质积累。CLA和ARA联合使用可使肝脏PGE（2）水平比单独使用CLA时有所提高，但各组间PGE（1）水平无显著差异。总之，CLA诱导的脂肪肝可通过与ARA联合给药来减轻，并且这些脂肪酸的组合保持了CLA的抗肥胖作用。
Conjugated linoleic acid (CLA) has anti-obesity effects, but induces fatty liver in mice. The present study investigated whether co-administration of arachidonic acid (ARA) attenuates fat accumulation in the mouse liver induced by CLA. Male mice (8 weeks old) were given diets with either no addition of dietary fat (control), 3 % linoleic acid (LA), 3 % CLA, 3 % CLA+1 % ARA, or 3 % CLA+2 % ARA for 4 weeks. The perirenal fat weight in ARA-treated groups decreased similarly as with CLA alone, when compared to control or LA. Plasma TAG concentration was significantly higher in the CLA group than in either CLA+ARA group, while plasma cholesterol and NEFA concentrations did not vary among the groups. In contrast to visceral fat, liver weight was significantly higher in the CLA group than in the control or LA groups, and the effects of CLA were attenuated by ARA. TAG and cholesterol were markedly accumulated in the liver with dietary CLA, whereas co-administration with ARA, at either concentration, suppressed CLA-induced lipid accumulation. Liver PGE(2) was enhanced by a combination of CLA and ARA when compared with CLA alone, but PGE(1) level was not significantly different among groups. In conclusion, fatty liver induced by CLA was attenuated by co-administration with ARA, furthermore, a combination of these fatty acids maintained the anti-obese effect of CLA.