ACTIVATION OF MULTIPLE TRANSCRIPTION FACTOR GENES BY TETRAHYDROCANNABINOL IN RAT FOREBRAIN
ACTIVATION OF MULTIPLE TRANSCRIPTION FACTOR GENES BY TETRAHYDROCANNABINOL IN RAT FOREBRAIN
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DOI：
10.1097/00001756-199406020-00028
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发表时间：
1994-06-02
期刊：
影响因子：
1.7
通讯作者：
VANDERHAEGHEN, JJ
中科院分区：
文献类型：
--
作者：
MAILLEUX, P;VERSLYPE, M;VANDERHAEGHEN, JJ
delta-9-TETRAHYDROCANNABINOL (THC) is a major psychoactive component of cannabis. We have recently localized a receptor for THC in the forebrain and found in the caudate-putamen that its gene expression is modulated by glucocorticoids, dopamine and glutamate. Here, we report for the first time, using quantitative in situ hybridization, that acute THC (5 mg kg(-1), i.p.) regulates the mRNA levels of multiple immediate early genes in the adult rat forebrain. Twenty minutes after a single THC injection, significant increases in concentration of the mRNAs for C-FOS, C-JUN and ZIF-268 were observed in the cingulate cortex (75, 45 and 37%) and for C-FOS and ZIF-268 in the fronto-parietal cortex (60 and 64%) and caudate-putamen (81 and 32%) while JUN-D mRNA levels were not changed. These transcription factor genes might mediate putative THC modulation of neurotransmitter gene expression.
