A study on prescribing patterns of antihypertensives in geriatric patients.
A study on prescribing patterns of antihypertensives in geriatric patients.
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DOI：
10.4103/2229-3485.103595
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发表时间：
2012-10
影响因子：
--
通讯作者：
Kunduru BR
中科院分区：
文献类型：
--
作者：
Mohd AH;Mateti UV;Konuru V;Parmar MY;Kunduru BR
高血压是全球心血管疾病发病率和死亡率的主要原因。本研究的主要目的是评估老年患者抗高血压药物的处方模式。在门诊部进行了为期6个月的前瞻性观察研究。纳入了根据JNC-7指南诊断为高血压的老年患者和接受或处方抗高血压药物的患者。在为期六个月的研究期间，共分析了100张处方。72%的患者年龄在65-67岁之间，男性患者比例更高，为69%。在研究期间，80%的患者为收缩期高血压前期（80-89 mmHg）和舒张期高血压（120-139 mmHg），其次为I期高血压和II期高血压。研究中涉及的最常见药物类别为钙通道阻滞剂（37%），其次为血管紧张素II受体拮抗剂（21%），研究人群中最常处方的药物为Amploid（37%）、氯沙坦（11%）和替米沙坦（10%）。本研究涉及的最常见的降压固定剂量复方治疗为替米沙坦+氢氯噻嗪15%，本研究涉及的最常见的两种药物复方治疗为安格列+阿替洛尔7%，其次为美托洛尔+安格列1%。我们的研究表明，最常见的处方药物类别是钙通道阻滞剂，其次是血管紧张素II受体拮抗剂，高血压患者中的抗高血压药物组合相当可观，这种做法对总体血压控制产生了积极影响。
Hypertension is a leading contributor to the global burden of cardiovascular morbidity and mortality. The main objective of the present study was to assess the prescribing patterns for antihypertensives in geriatric patients. A Prospective observational study was carried out for the period of six months in an out-patient department. Elderly patients who have been diagnosed with hypertension as per JNC-7 guidelines and patients receiving or prescribed with antihypertensive drugs were included. A total of 100 prescriptions were analyzed during the six-month study period. 72% of the patients were in the age group of 65-67 years and this was found to be higher in men 69%. During the study period 80% of the patients were Pre-Hypertensive systolic (80-89 mmHg) and Diastolic (120-139 mmHg) followed by Stage-I Hypertension and Stage-II Hypertension. The most common drug classes involved in the study was Calcium Channel Blockers 37% followed by Angiotensin II receptor antagonists 21% and the most commonly prescribed drugs in the study population were Amlodipine 37%, Losartan 11% and Telmisartan 10%. The most common anti-hypertensive fixed dose combination therapy involved in the study was Telmisartan + Hydrochlorothiazide 15% and most common two drug combination therapy involved in the study was Amlodipine + Atenolol 7% followed by Metoprolol + Amlodipine 1%. Our study shows that the most commonly prescribed drug classes involved were Calcium Channel Blockers followed by Angiotensin II receptor antagonists and the anti-hypertensive drug combinations among hypertensive patients were considerable and this practice positively impacted on the overall blood pressure control.