Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation
Delivery of nanoparticle antigens to antigen-presenting cells: from extracellular specific targeting to intracellular responsive presentation
复制标题
将纳米颗粒抗原递送至抗原呈递细胞：从细胞外特异性靶向到细胞内响应性呈递
DOI：
10.1016/j.jconrel.2021.03.027
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发表时间：
2021
影响因子：
10.8
通讯作者：
Gang Chen
中科院分区：
文献类型：
--
作者：
Fei Wang;Aftab Ullah;Xuelian Fan;Zhou Xu;Rongling Zong;Xuewen Wang;Gang Chen
合适的递送系统可以改善抗原针对各种感染或肿瘤的免疫效果。抗原提呈细胞（Antigen-presenting cells，APC）是机体内专门捕获和加工抗原的细胞，是天然免疫和获得性免疫的重要环节。将具有靶向部分的疫苗递送系统功能化至APC是激发有效免疫应答的有前景的策略。此外，抗原的内化和细胞内分布与下游免疫应答的启动密切相关。随着对细胞内微环境和抗原呈递机制的深入理解，设计用于响应内源性和外部刺激的载体可以调节抗原加工和呈递途径，这对免疫应答的类型至关重要。本文就抗原的细胞外靶向递送和细胞内刺激-应答策略进行综述，为疫苗递送系统的合理设计提供参考。
An appropriate delivery system can improve the immune effects of antigens against various infections or tumors. Antigen-presenting cells (APCs) are specialized to capture and process antigensin vivo, which link the innate and adaptive immune responses. Functionalization of vaccine delivery systems with targeting moieties to APCs is a promising strategy for provoking potent immune responses. Additionally, the internalization and intracellular distribution of antigens are closely related to the initiation of downstream immune responses. With a deeper understanding of the intracellular microenvironment and the mechanisms of antigen presentation, vehicles designed to respond to endogenous and external stimuli can modulate antigen processing and presentation pathways, which are critical to the types of immune response. Here, an overview of extracellular targeting delivery of antigens to APCs and intracellular stimulus-responsiveness strategies is provided, which might be helpful for the rational design of vaccine delivery systems.