Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.
Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.
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阿尔茨海默病发病机制的进展：关注 Tau 介导的神经变性
DOI：
10.1186/2047-9158-1-24
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发表时间：
2012-12-15
影响因子：
12.6
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
Duan Y;Dong S;Gu F;Hu Y;Zhao Z
除了老年斑和脑淀粉样血管病变外，tau蛋白的过度磷酸化和神经细胞内神经原纤维缠结(NFTs)的形成是AD脑的另一个神经病理特征。Tau是一种微管相关蛋白，主要定位于神经元的轴突，其主要功能是维持微管的稳定性。当tau磷酸化和去磷酸化之间的平衡向前者倾斜时，tau被过度磷酸化，游离tau组分的水平上升。Tau蛋白的过度磷酸化和NFTs的形成是AD脑内特有的神经病理特征。我们在以前的综述中已经讨论了Aβ在AD中的作用，本文重点介绍了tau介导的AD病理的最新进展，主要包括tau过度磷酸化、tau病理的传播以及tau与Aβ的关系。
In addition to senile plaques and cerebral amyloid angiopathy, the hyperphosphorylation of tau protein and formation of intraneuronal neurofibrillary tangles (NFTs) represents another neuropathological hallmark in AD brain. Tau is a microtubule-associated protein and localizes predominantly in the axons of neurons with the primary function in maintaining microtubules stability. When the balance between tau phosphorylation and dephosphorylation is changed in favor of the former, tau is hyperphosphorylated and the level of the free tau fractions elevated. The hyperphosphorylation of tau protein and formation of NFTs represent a characteristic neuropathological feature in AD brain. We have discussed the role of Aβ in AD in our previous review, this review focused on the recent advances in tau-mediated AD pathology, mainly including tau hyperphosphorylation, propagation of tau pathology and the relationship between tau and Aβ.