Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus
Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus
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DOI：
10.1530/eje.0.1510573
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发表时间：
2004-11-01
影响因子：
5.8
通讯作者：
Sumida, Y
中科院分区：
文献类型：
--
作者：
Katsuki, A;Urakawa, H;Sumida, Y
目的：探讨2型糖尿病患者循环活性胃饥饿素水平与腹部肥胖、血清胰岛素及胰岛素抵抗的关系。设计：我们使用放射免疫测定（RIA）试剂盒测量了18例肥胖和18例非肥胖2型糖尿病患者胃饥饿素活性形式的血浆水平。在正糖高胰岛素钳夹研究中，通过计算机断层扫描（CT）测量体脂肪积累，通过葡萄糖输注率（GIR）测量胰岛素抵抗。结果：肥胖合并2型糖尿病患者血浆ghrelin水平明显低于非肥胖患者。2型糖尿病患者血浆ghrelin水平与BMI （r = - 0.505, P < 0.01）、内脏（r = - 0.444, P < 0.01）、皮下（r = - 0.506, P < 0.01）、总脂肪面积（r = - 0.534, P < 0.01）、血清胰岛素水平（r = - 0.513, P < 0.01）、GIR （r = 0.478, P < 0.01）均有显著相关性。2型糖尿病患者调整BMI后，血浆ghrelin水平与血清胰岛素水平（F = 8.468, P < 0.05）或GIR水平（F = 8.522, P < 0.05）显著相关。结论：血浆活性胃饥饿素水平降低与2型糖尿病患者腹部肥胖、高胰岛素血症和胰岛素抵抗显著相关。与胰岛素抵抗相关的高胰岛素血症可能抑制2型糖尿病患者血浆中活性胃饥饿素的水平。
Objective: To investigate the relationship between the circulating level of active ghrelin and abdominal adiposity, serum levels of insulin or insulin resistance in patients with type 2 diabetes mellitus.Design: We measured the plasma levels of the active form of ghrelin in 18 obese and 18 nonobese patients with type 2 diabetes mellitus using a radioimmunoassay (RIA) kit. Body fat accumulation was measured by computed tomography (CT) and insulin resistance by the glucose infusion rate (GIR) during an euglycemic hyperinsulinemic clamp study.Results: Plasma levels of ghrelin in obese patients with type 2 diabetes mellitus were significantly decreased compared with nonobese patients. There were significant correlations between the plasma levels of ghrelin and BMI (r = - 0.505, P < 0.01), visceral (r = - 0.444, P < 0.01), subcutaneous (r = - 0.506, P < 0.01) and total (r = - 0.534, P < 0.01) fat area, serum levels of insulin (r = - 0.513, P < 0.01) or GIR (r = 0.478, P < 0.01) in type 2 diabetic patients. The plasma level of ghrelin was significantly associated with serum levels of insulin (F = 8.468, P < 0.05) or GIR (F = 8.522, P < 0.05) after adjustment for BMI in patients with type 2 diabetes mellitus.Conclusions: Decreased plasma levels of active ghrelin are significantly associated with abdominal adiposity, hyperinsulinemia and insulin resistance in type 2 diabetic patients. Hyperinsulinemia associated with insulin resistance may suppress plasma levels of active ghrelin in patients with type 2 diabetes mellitus.