Pathophysiology of Meniere's Disease
Pathophysiology of Meniere's Disease
复制标题
梅尼埃病的病理生理学
DOI：
10.5772/66388
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发表时间：
2017
影响因子：
3.7
通讯作者：
S. Gokhale
中科院分区：
文献类型：
--
作者：
S. Gokhale
梅尼埃病以其眩晕、平衡和听力障碍三联征为特征，其病理生理学尚未得到最终的概述。任何理论都必须阐明自然进展的所有方面，包括前庭和听觉症状。虽然中心法则围绕内淋巴积水，但该理论并非没有缺陷，例如它无法解释患者所见的所有生理变化，或者通常没有症状。虽然在颞骨组织病理学中观察到一些退行性变化，但它们不一定能解释疾病发生和进展的事件顺序。本章探讨了该疾病的病理生理学，重点关注水肿理论，同时提出了支持和反对该理论的证据。内耳生理的各种变化，如压力变化、离子不平衡、耳蜗电位；在人类和动物模型中进行了描述。讨论了症状的其他解释。本章简要介绍了与梅尼埃病（和积水）相关的病因学，旨在帮助更深入地了解该过程与临床和实验结果的关系。对这一过程的清晰理解不仅可以指导临床管理以提高生活质量，还可以指导未来研究工作的方向。
Meniere’s disease, with its characteristic symptom triad of vertigo, balance and hear‐ ing disorders has yet to have its pathophysiology outlined conclusively. Any theory must elucidate all aspects of the natural progression, including vestibular and audi‐ tory symptoms. While the central dogma revolves around endolymphatic hydrops, this theory is not without flaws, such as its inability to explain all the physiological changes seen in patients, or the often absence of symptoms. While several degenera‐ tive changes are observed in temporal bone histopathology, they do not necessarily explain the sequence of events in the development and progress of the disease. This chapter explores the pathophysiology of the disease, focusing on the hydrops theory, while presenting evidence for and against it. Various changes in the inner ear physi‐ ology such as pressure changes, ionic disequilibrium, endocochlear potentials; in human and animal models are described. Alternative explanations for symptoms are discussed. This chapter touches briefly upon etiology associated with Meniere’s (and hydrops), and aims to assist a deeper understanding of the relationship of the process to clinical and experimental findings. A clear understanding of the process guides not only the clinical management to improve quality of life but also the direction of future research endeavors.
影响因子：
3.5
作者：
Requena, Teresa;Cabrera, Sonia;Lopez-Escamez, Jose A.
通讯作者：
Lopez-Escamez, Jose A.