Neuronal activity in the globus pallidus in chorea caused by striatal lacunar infarction
Neuronal activity in the globus pallidus in chorea caused by striatal lacunar infarction
复制标题
纹状体腔隙性梗死引起的舞蹈症苍白球神经元活动
作者：
T. Hashimoto;H. Morita;T. Tada;Tetsuhiro Maruyama;Yuzo Yamada;S. Ikeda
对一名因纹状体腔隙性梗死引起的偏侧舞蹈症患者进行了苍白球切开术。在苍白球内段感觉运动区内侧部分的神经外科损伤后，下肢的舞蹈症减少，在同一区域的外侧部分的额外损伤后，上肢的舞蹈症消失。术中神经元记录显示，与帕金森病患者相比，苍白球的平均放电率较低，且放电不规则。这些结果表明，舞蹈病与纹状体梗死是由阶段性的神经元活动与低发射率在苍白球和舞蹈病的神经通路有一个功能性的组织在苍白球。
Pallidotomy was performed in a patient with hemichorea caused by lacunar infarction in the striatum. Chorea in the lower limb was reduced after a neurosurgical lesion in the medial portion of the sensorimotor territory of the internal segment of the globus pallidus, and chorea in the upper limb disappeared after an additional lesion in the lateral portion of that same area. Intraoperative neuronal recording revealed that mean firing rates were low, and that firing was irregular in the globus pallidus compared with off‐state parkinsonian patients. These results suggest that chorea with striatal infarction is driven by phasic neuronal activity with a low firing rate in the globus pallidus and that the neural pathway of chorea has a functional somatotopical organization in the globus pallidus.
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影响因子：
4
作者：
TRANEBJAERG, L;SCHWARTZ, C;LUBS, H
通讯作者：
LUBS, H
影响因子：
3.5
作者：
Pilz, DT;Kuc, J;Ledbetter, DH
通讯作者：
Ledbetter, DH
XLMR 基因：1998 年更新。
DOI：
--
发表时间：
1999
期刊：
American journal of medical genetics.
影响因子：
--
作者：
Lubs,H;Chiurazzi,P;Arena,J;Schwartz,C;Tranebjaerg,L;Neri,G
通讯作者：
Neri,G
影响因子：
2.5
作者：
DELONG, MR;CRUTCHER, MD;GEORGOPOULOS, AP
通讯作者：
GEORGOPOULOS, AP
影响因子：
4.1
作者：
Vitek, JL;Bakay, RAE;DeLong, MR
通讯作者：
DeLong, MR