Novel mobility test to assess functional vision in patients with inherited retinal dystrophies
Novel mobility test to assess functional vision in patients with inherited retinal dystrophies
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DOI：
10.1111/ceo.13022
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发表时间：
2018-04-01
影响因子：
4
通讯作者：
High, Katherine A.
中科院分区：
文献类型：
--
作者：
Chung, Daniel C.;McCague, Sarah;High, Katherine A.
ImportanceThis新的终点跟踪功能性视力变化的患者与遗传性视网膜营养不良（IRDs）随着时间的推移。BackgroundThe目的的研究是为了确定是否多亮度移动测试（MLMT）可以检测功能性视力变化随着时间的推移，在受试者与IRDs和评估自然史和潜在的影响，调查agents.DesignThis是一个前瞻性的，观察性研究。六十（29正常视力和31视力受损）有资格; 54（28视力受损和26正常视力）完成所有测试visits.MethodsSubjects导航MLMT课程三次超过1 year。在每次访问时，受试者完成测试，使用单个眼睛，双眼，在多达9个标准化，增加亮度水平（范围1至400勒克斯）。准确性和速度进行了评估，并与视力（VA），视野（VF）和视觉功能questionnaire.Main Outcome MeasuresAccuracy和速度的正常和视力受损的受试者对MLMT，和MLMT的可靠性和内容效度的主要结局measures.ResultsMLMT区分视力正常的视力受损的受试者。所有对照受试者在所有测试的光照水平下都通过了所有MLMT尝试。视力受损的受试者的表现差异很大;有些人在12年内下降。低于特定VA和VF阈值时，性能明显下降。在两个基线访问的性能一致性是高的：准确性的相关性分别为94%和98%的最低共同和最高共同勒克斯levels.Conclusions和RelevanceMLMT区分视力受损的控制人群，并在视力受损的受试者，确定了一系列的性能，并跟踪性能下降随着时间的推移，符合这些渐进的条件。
ImportanceThis novel endpoint tracks functional vision changes in patients with inherited retinal dystrophies (IRDs) over time.BackgroundThe aims of the study were to determine whether a multi-luminance mobility test (MLMT) can detect functional vision changes over time in subjects with IRDs and to assess natural history and potential effects of investigational agents.DesignThis is a prospective, observational study.ParticipantsSixty-two subjects were enrolled. Sixty (29 normal sighted and 31 visually impaired) were eligible; 54 (28 visually impaired and 26 normal-sighted) completed all testing visits.MethodsSubjects navigated MLMT courses three times over 1year. At each visit, subjects completed testing using individual eyes, and both eyes, at up to nine standardized, increasing luminance levels (range 1 to 400lux). Accuracy and speed were evaluated and compared with visual acuity (VA), visual field (VF) and a visual function questionnaire.Main Outcome MeasuresAccuracy and speed of normal and visually impaired subjects on MLMT, and reliability and content validity of MLMT were the main outcome measures.ResultsMLMT distinguished normal-sighted from visually impaired subjects. All control subjects passed all MLMT attempts at all tested light levels. Visually impaired subjects' performance varied widely; some declined over 1year. Performance declined markedly below certain VA and VF thresholds. Concordance on performance on two baseline visits was high: correlations for accuracy were 94% and 98% for lowest common and highest common lux levels.Conclusions and RelevanceMLMT differentiated visually impaired from control populations and, in visually impaired subjects, identified a range of performances; and tracked performance declines over time, consistent with these progressive conditions.