The Leptospira interrogans lexA gene is not autoregulated
The Leptospira interrogans lexA gene is not autoregulated
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DOI：
10.1128/jb.187.16.5841-5845.2005
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发表时间：
2005-08-01
影响因子：
3.2
通讯作者：
Barbe, J
中科院分区：
文献类型：
--
作者：
Cuñé, J;Cullen, P;Barbe, J
足迹和突变实验表明，问号钩端螺旋体LexA与recA启动子中的回文TTTGN(5)CAAA结合，但不与LexA启动子中的回文TTTGN(5)CAAA结合。在计算机分析中发现，其他典型的SOS基因都不受LexA的直接控制，这使得钩端螺旋体LexA基因成为第一个被描述的非自我调节的基因。
Footprinting and mutagenesis experiments demonstrated that Leptospira interrogans LexA binds the palindrome TTTGN(5)CAAA found in the recA promoter but not in the lexA promoter. In silico analysis revealed that none of the other canonical SOS genes is under direct control of LexA, making the leptospiral lexA gene the first described which is not autoregulated.