Investigation of Physiological Swelling on Conductivity Distribution in Lower Leg Subcutaneous Tissue by Electrical Impedance Tomography.
Investigation of Physiological Swelling on Conductivity Distribution in Lower Leg Subcutaneous Tissue by Electrical Impedance Tomography.
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DOI：
10.2478/joeb-2020-0004
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发表时间：
2020-01
影响因子：
--
通讯作者：
Takei M
中科院分区：
文献类型：
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作者：
Ogawa R;Baidillah MR;Akita S;Takei M
目前迫切需要一种非侵入性测量技术，能够通过定位隔室内的异常来准确识别皮下脂肪组织（SAT）的生理状况变化或异质性。本文旨在探讨电阻抗断层扫描（EIT）作为生物电阻抗谱（BIS）增强方法评估皮下脂肪组织间质液的可行性。在这里，我们展示了一个可穿戴的16电极传感器的EIT的初步结果。提出了基于图像的基于脂肪加权阈值的参考EIT方法。为了评估新方法的性能，我们进行了生理肿胀实验，并应用多频生物阻抗分析（MFBIA）与EIT结果进行了比较。实验结果表明，该方法能够有效地分辨出生理肿胀状态，并能有效地去除意外背景噪声。此外，MFBIA数据显示，皮下电导率变化与细胞外水量变化具有良好的相关性；相关系数R2 = 0.927。结果表明，该方法具有广阔的应用前景。
There is a strong need for a non-invasive measurement technique that is capable of accurately identifying the physiological condition change or heterogeneity of subcutaneous adipose tissue (SAT) by localizing the abnormalities within the compartment. This paper aims to investigate the feasibility of Electrical Impedance Tomography (EIT) to assess the interstitial fluid in subcutaneous adipose tissue as an enhancement method of bioelectrical impedance spectroscopy (BIS). Here, we demonstrate the preliminary result of EIT with a wearable 16 electrodes sensor. The image-based reference EIT with fat weighted threshold method is proposed. In order to evaluate the performance of our novel method, a physiological swelling experiment is conducted, and Multi-Frequency Bioelectrical Impedance Analysis (MFBIA) is also applied as a comparison with EIT results. The experimental results showed that the proposed method was able to distinguish the physiological swelling condition and effectively to remove the unexpected background noise. Furthermore, the conductivity variation in the subcutaneous layer had a good correlation with extracellular water volume change from MFBIA data; the correlation coefficient R2 = 0.927. It is concluded that the proposed method provides a significant prospect for SAT assessment.