SAFE DISPOSAL OF CARCINOGENIC NITROSAMINES
SAFE DISPOSAL OF CARCINOGENIC NITROSAMINES
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DOI：
10.1093/carcin/4.3.315
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发表时间：
1983-01-01
期刊：
影响因子：
4.7
通讯作者：
KEEFER, LK
中科院分区：
文献类型：
--
作者：
LUNN, G;SANSONE, EB;KEEFER, LK
描述了一种简单的一步化学降解研究实验室产生的亚硝胺残留物的方法。用A-N合金粉末和碱水处理后，所研究的11种亚硝胺迅速还原为相应的胺。肼是作为过渡中间体产生的，但在所使用的条件下，这些潜在的致癌物也很容易被还原。在最终的反应混合物中，除了胺、氨和某些情况下的醇以外，没有检测到任何产物。除在丙酮或二氯甲烷溶液中的反应有时缓慢、不完全和/或导致不明产物外，还原在所测试的所有其他溶剂系统中都进行得很顺利；因此，不推荐在这些溶剂中使用该程序。该方法高效、可靠、廉价，被推荐为将可能致癌的亚硝胺降解为无害产品的首选方法之一。详细介绍了它在实验室中常见的去污和处理问题中的应用。文中给出了S压下工艺优于其他6种压下工艺的数据。
A simple 1-step procedure for chemically degrading nitrosamine residues generated in the research laboratory is described. Treatment with A-N alloy powder and aqueous alkali rapidly reduced all 11 nitrosamines studied to the corresponding amines. Hydrazines were produced as transitory intermediates, but these potential carcinogens were also easily reduced under the conditions employed. No products except amines, ammonia and in some cases alcohols were detected in the final reaction mixtures. Reduction proceeded smoothly in every other solvent system tested, except that reactions in acetone or dichloromethane solution were sometimes slow, incomplete and/or led to unidentified products; therefore, the procedure cannot be recommended for use in these solvents. The method was efficient, reliable and inexpensive and was recommended as 1 of the preferred means of degrading potentially carcinogenic nitrosamines to innocuous products. Details of its application to some decontamination and disposal problems commonly encountered in the research laboratory are provided. Data illustrating this procedure''s advantages over 6 other reducing systems are presented.