Vertebrate Nervous System Posteriorization: Grading the Function of Wnt Signaling
Vertebrate Nervous System Posteriorization: Grading the Function of Wnt Signaling
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DOI：
10.1002/dvdy.24230
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发表时间：
2015-03-01
影响因子：
2.5
通讯作者：
Lekven, Arne C.
中科院分区：
文献类型：
--
作者：
Green, David;Whitener, Amy E.;Lekven, Arne C.
在脊椎动物神经板中建立前后同一性是一个几十年来研究的主题，但对后部化的分子解释直到20世纪80年代末才开始揭示。从几项关键研究中发现了一个模型，该模型将Wnt信号确定为关键的后化因子，证据表明，它以一种浓度依赖的方式指定前后命运。在这篇综述中，我们考虑了后置研究的历史背景，并对Wnt依赖的后置模型进行了评估。随着关于许多信号配体递送方式的新信息，我们提出了替代方案来协调Wnt梯度模型与复杂的原肠形成过程和潜在的Wnt递送的非分泌机制。《发展动力学》244：507-512,2015。(C)2014年威利期刊公司。
The establishment of anteroposterior identity in the vertebrate neural plate has been a subject of investigation for decades, but molecular explanations of posteriorization were only revealed beginning in the late 1980s. A model has emerged from several key studies that identifies Wnt signaling as a key posteriorizing agent, which evidence suggests specifies anteroposterior fates in a concentration-dependent manner. In this review, we consider the historical context of posteriorization studies and evaluate models for Wnt-dependent posteriorization. With new information about the mode of delivery of many signaling ligands, we propose alternative scenarios to reconcile the Wnt gradient model with the complex process of gastrulation and potential non-secretory mechanisms of Wnt delivery. Developmental Dynamics 244:507-512, 2015. (c) 2014 Wiley Periodicals, Inc.