Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin E2 in anaesthetized rats
Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin E2 in anaesthetized rats
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脑室内注射前列腺素E2对麻醉大鼠胃酸分泌的抑制作用
DOI：
10.1111/j.1476-5381.1983.tb09372.x
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发表时间：
1983
影响因子：
7.3
通讯作者：
J. Puurunen
中科院分区：
文献类型：
--
作者：
J. Puurunen
1.侧脑室注射前列腺素E_2（PGE_2）对麻醉大鼠胃酸分泌的影响。2侧脑室注射1和3 μg PGE2可剂量依赖性地抑制胰岛素、迷走神经电刺激和乙酰胆碱诱导的胃酸分泌。3静脉注射1、3和10 μg PGE2对胰岛素刺激的胃酸排出量没有影响。4结果表明，在i.c.v.给药后，PGE2通过中枢作用而不是从中枢神经系统渗漏后通过外周作用来抑制胃酸分泌。
1 The effect of intracerebroventricularly (i.c.v) administered prostaglandin E2 (PGE2) on gastric acid secretion was studied in anaesthetized rats. 2 Intracerebroventricular injections of 1 and 3 μg of PGE2 inhibited gastric acid secretion induced by insulin, electrical vagal stimulation and acetylcholine in a dose‐dependent manner. 3 Intravenous injections of 1, 3 and 10 μg of PGE2 had no effect on insulin‐stimulated gastric acid output. 4 The results indicate that upon i.c.v. administration PGE2 inhibits gastric acid secretion by acting centrally and not peripherally after leakage from the central nervous system.