Ideal lifestyles against colorectal tumorigenesis: with explanation for the impact of exercise or obesity on colorectal tumor development
Ideal lifestyles against colorectal tumorigenesis: with explanation for the impact of exercise or obesity on colorectal tumor development
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DOI：
10.7600/jspfsm.67.141
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发表时间：
2018-04
影响因子：
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通讯作者：
M. Mutoh;Shuya Tamura;Takahiro Hamoya;Gen Fujii
中科院分区：
文献类型：
--
作者：
M. Mutoh;Shuya Tamura;Takahiro Hamoya;Gen Fujii
在日本，由于西化的生活方式，包括结肠直肠癌在内的肥胖相关癌症正在增加，例如减少体育活动和增加高脂肪饮食。内脏脂肪组织的过度积累导致胰岛素抵抗、氧化应激和脂肪细胞因子失衡，这些因素被认为与结直肠肿瘤的发生有关。在这篇综述文章中，我们专注于每一个个体相关的条件，特别是肥胖和运动，结直肠肿瘤的发展与靶向分子在体内和体外研究揭示之间的关系。此外，潜在的结直肠癌预防靶向这些分子进行了讨论。Jpn J Phys Fitness Sports Med，67（2）：141-146（2018）
Obesity-associated cancers, including colorectal cancer, are increasing in Japan with Westernized lifestyles as exemplified by reduced physical activity and increased high-fat diet. An excessive accumulation of visceral adipose tissue causes insulin resistance, oxidative stress and adipocytokine imbalance, and these factors are suggested to be involved in colorectal tumorigenesis. In this review article, we focus on the relationships between each of the individual associated conditions, especially obesity and exercise, and colorectal tumor development with targeting molecules revealed by in vivo and in vitro studies. Furthermore, the potential for colorectal cancer prevention by targeting these molecules is discussed. Jpn J Phys Fitness Sports Med, 67(2): 141-146 (2018)