Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.
Cinnamon extract promotes type I collagen biosynthesis via activation of IGF-I signaling in human dermal fibroblasts.
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DOI：
10.1021/jf2043357
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发表时间：
2012-01
影响因子：
6.1
通讯作者：
Naoko Takasao;K. Tsuji-Naito;Seiko Ishikura;Azusa Tamura;M. Akagawa
中科院分区：
文献类型：
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作者：
Naoko Takasao;K. Tsuji-Naito;Seiko Ishikura;Azusa Tamura;M. Akagawa
随着年龄的增长，胶原网络的破坏会导致皮肤活性降低。因此，恢复停滞的胶原蛋白合成可以帮助保护皮肤对抗衰老。我们利用人真皮成纤维细胞在各种食物中寻找I型胶原生物合成诱导物质，发现肉桂提取物促进胶原生物合成。肉桂提取物能有效上调I型胶原mRNA和蛋白表达水平，但无细胞毒性。通过HPLC和NMR分析，我们发现肉桂醛是促进胶原蛋白表达的主要活性成分。由于胰岛素样生长因子- i （IGF-I）是成纤维细胞中胶原生物合成最有效的刺激物，我们研究了肉桂醛对IGF-I信号传导的影响。肉桂醛处理显著增加了IGF-I受体及其下游信号分子如胰岛素受体底物-1和Erk1/2的磷酸化水平，且不依赖于IGF-I。这些结果表明肉桂提取物在皮肤抗衰老治疗中是有用的。
The breakdown of collagenous networks with aging results in hypoactive changes in the skin. Accordingly, reviving stagnant collagen synthesis can help protect dermal homeostasis against aging. We searched for type I collagen biosynthesis-inducing substances in various foods using human dermal fibroblasts and found that cinnamon extract facilitates collagen biosynthesis. Cinnamon extract potently up-regulated both mRNA and protein expression levels of type I collagen without cytotoxicity. We identified cinnamaldehyde as a major active component promoting the expression of collagen by HPLC and NMR analysis. Since insulin-like growth factor-I (IGF-I) is the most potent stimulator of collagen biosynthesis in fibroblasts, we examined the effect of cinnamaldehyde on IGF-I signaling. Treatment with cinnamaldehyde significantly increased the phosphorylation levels of the IGF-I receptor and its downstream signaling molecules such as insulin receptor substrate-1 and Erk1/2 in an IGF-I-independent manner. These results suggested that cinnamon extract is useful in antiaging treatment of skin.