Elevated C-reactive protein levels in overweight and obese adults
Elevated C-reactive protein levels in overweight and obese adults
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DOI：
10.1001/jama.282.22.2131
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发表时间：
1999-12-08
影响因子：
120.7
通讯作者：
Harris, TB
中科院分区：
文献类型：
--
作者：
Visser, M;Bouter, LM;Harris, TB
背景人类脂肪组织表达并释放促炎细胞因子白细胞介素6，可能会在体内脂肪过多的人中诱发低度全身性炎症。目的通过血清C反应蛋白（CRP）水平来测试超重和肥胖是否与低度全身性炎症相关。设计和设置第三次全国健康和营养检查调查，代表1988年至1994年的美国人口，参与者共有16 616名男性和女性。 17 岁或以上的非孕妇 主要结果指标 CRP 水平升高 0.22 mg/dL 或更高，以及更严格的临床 CRP 水平升高超过 1.00 mg/dL。 结果 人群中，分别有 27.6% 和 6.7% 的人群存在 CRP 水平升高和临床升高 CRP 水平。超重（体重指数 [BMI]，25-29.9 kg/m(2)）和肥胖（BMI，大于或等于 30 kg/m(2)）的人比正常体重的人（BMI，
Context Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat.Objective To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level.Design and Setting The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994,Participants A total of 16 616 men and nonpregnant women aged 17 years or olderMain Outcome Measures Elevated CRP level of 0.22 mg/dL or more and a more stringent clinically raised CRP level of more than 1.00 mg/dL.Results Elevated CRP levels and clinically raised CRP levels were present in 27.6% and 6.7% of the population, respectively. Both overweight (body mass index [BMI], 25-29.9 kg/m(2)) and obese (BMI, greater than or equal to 30 kg/m(2)) persons were more likely to have elevated CRP levels than their normal-weight counterparts (BMI,