CHRONIC EFFECTS OF DIETARY FUMONISIN ON THE HEART AND PULMONARY VASCULATURE OF SWINE
CHRONIC EFFECTS OF DIETARY FUMONISIN ON THE HEART AND PULMONARY VASCULATURE OF SWINE
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DOI：
10.1006/faat.1994.1136
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发表时间：
1994-11-01
期刊：
影响因子：
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通讯作者：
ROTTINGHAUS, GE
中科院分区：
文献类型：
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作者：
CASTEEL, SW;TURK, JR;ROTTINGHAUS, GE
伏马菌素，在感染串珠镰刀菌的玉米中产生的真菌毒素。在几个物种中具有肝脏毒性，并在实验室大鼠中引起肝癌，在马物种中引起白质脑软化症。和猪暴发性肺水肿。到目前为止，伏马菌素对猪的影响只涉及诱导急性暴发性疾病戏剧性发展所需的高水平，通常是致命的。肺水肿。不那么耸人听闻，但同样重要的是，伏马菌素对猪健康的长期影响。在第一个试验中，6头母猪随机饲喂含有100 mg伏马菌素B-1(FB1)/公斤的配方日粮10天，然后再饲喂含有190 mg伏马菌素B-1/公斤的日粮，最长达83天。在第二个试验中，5头母猪随机饲喂含有150-170 mg FB1/kg的日粮，最长达210天。伏马菌素B-2(FB2)的浓度是FB1的31+/-2%。选择体重匹配的对照组进行心脏参数比较。喂食伏马菌素至少93天的猪出现肝脏结节状增生。对四头暴露于饲料伏马菌素6个月的猪的心脏和肺的显微镜检查和心脏组织的重量测量的证据表明，肺血管是慢性暴露的目标。这项研究提供了更多证据，将伏马菌素诱导的各种动物器官系统损伤的发病机制与血管机制联系起来。(C)1994年毒理学学会。
Fumonisins, mycotoxins produced in Fusarium moniliforme-infected corn. are hepatotoxic in several species and induce hepatocarcinomas in laboratory rats, leukoencephalomalacia in equine species. and fulminant pulmonary edema in swine. To date, the effects of fumonisin on pigs has dealt solely with the high levels required to induce the dramatic development of acute fulminant, and usually lethal. pulmonary edema. Less sensational, but equally important, are the chronic effects of fumonisin on swine health. In the first trial, six gilts were fed, ad libitum, a formulated complete ration containing 100 mg fumonisin B-1 (FB1)/kg for 10 days followed by a ration containing 190 mg FB1/kg for up to 83 days. In the second trial, five gilts were fed, ad libitum, rations containing 150-170 mg FB1/kg for up to 210 days. The concentration of fumonisin B-2 (FB2) was 31 +/- 2% that of the FB1. Weight-matched controls were selected for cardiac parameter comparison. Pigs fed fumonisin for at least 93 days developed nodular hyperplasia of the liver. Evidence from the microscopic examination of heart and lungs and gravimetric measurements of cardiac tissues from four pigs exposed to dietary fumonisins for 6 months suggests that the pulmonary vasculature is a target of chronic exposure. This study provides additional evidence linking the pathogenesis of fumonisin-induced lesions in a variety of organ systems of various animal species to a vascular mechanism. (C) 1994 Society of Toxicology.