GFAP in early multiple sclerosis: A biomarker for inflammation
GFAP in early multiple sclerosis: A biomarker for inflammation
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DOI：
10.1016/j.neulet.2017.07.050
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发表时间：
2017-09-14
影响因子：
2.5
通讯作者：
Tumani, Hayrettin
中科院分区：
文献类型：
--
作者：
Kassubek, Rebecca;Gorges, Martin;Tumani, Hayrettin
目的：胶质纤维酸性蛋白（GFAP）作为复发缓解型多发性硬化（RRMS）和临床孤立综合征（CIS）的潜在生物标志物的作用一直存在争议。材料与方法：对18例RRMS患者、8例CIS患者和35例对照者的CSF中GFAP水平进行分析，并结合MRI资料分析急性和慢性炎性病变负荷。患者的GFAP水平高于对照组（p = 0.005），而RRMS和CIS中的GFAP水平之间没有差异。幕上或幕下钆增强病变的数量与GFAP水平之间没有相关性，而GFAP水平与幕下慢性炎性病变负荷之间存在相关性（p = 0.0035）。最重要的是，一个高度显着的相关性，可以观察到之间的GFAP水平和强度的钆增强作为一个参数的急性活动的炎症过程（p = 0.0002）。结论：GFAP似乎是一个有用的生物标志物高度活跃的急性炎症患者RRMS以及CIS。(C)2017爱思唯尔B.V.保留所有权利。
Objective: The role of Glial Fibrillic Acidic Protein (GFAP) as a potential biomarker for relapsing -remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) has been controversially discussed. The aim was to characterize the added value of GFAP levels in the CSF of RRMS and CIS patients in correlation with MRI lesion load.Materials & methods: GFAP levels in the CSF from 18 patients with RRMS, 8 patients with CIS and 35 controls were analyzed together with MRI data for acute and chronic inflammatory lesion load.Results: GFAP levels of patients vs. controls were higher (p = 0.005), while there was no difference between GFAP levels in RRMS and CIS. There was no correlation between the number of supra- or infratentorial gadolinium enhancing lesions and GFAP levels, while there was a correlation between GFAP levels with infratentorial chronic inflammatory lesion load (p = 0.0035). Most importantly, a highly significant correlation could be observed between GFAP levels and the intensity of gadolinium-enhancement as a parameter for the acute activity of inflammatory processes (p = 0.0002).Conclusions: GFAP seems to be a useful biomarker for highly active acute inflammation in patients with RRMS as well as with CIS. (C) 2017 Elsevier B.V. All rights reserved.