Automated Analysis of Intratidal Dynamics of Alveolar Geometry From Microscopic Endoscopy
Automated Analysis of Intratidal Dynamics of Alveolar Geometry From Microscopic Endoscopy
复制标题
通过显微内窥镜自动分析潮内肺泡几何形状的动力学
DOI：
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发表时间：
2010
影响因子：
4.6
通讯作者：
J. Guttmann
中科院分区：
文献类型：
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作者：
D. Schwenninger;K. Möller;Hui Liu;J. Guttmann
肺泡实质是呼吸系统的气体交换区域，在机械通气过程中容易受到机械性损伤。因此，肺保护性通气策略的发展需要更好地了解机械通气期间的肺泡动力学。在本文中，我们提出了一种新的方法，自动分析的潮气内的几何形状的胸膜下肺泡的基础上评价的视频帧记录肺泡显微镜在实验设置。我们的方法包括记录与显微内窥镜，从图像数据中提取特征，分析一个单一的帧，跟踪和分析单个肺泡的视频序列，并评估所获得的序列的肺泡几何数据。我们的方法能够自动分析2-D肺泡几何形状，具有足够的时间分辨率，以跟踪潮内动力学。所开发的方法和结果的再现性成功地验证了手动分割的视频帧。
Alveolar parenchyma, the gas exchange area of the respiratory system, is prone to mechanical damage during mechanical ventilation. Development of lung protective ventilation strategies therefore requires a better understanding of alveolar dynamics during mechanical ventilation. In this paper, we propose a novel method for automated analysis of the intratidal geometry of subpleural alveoli based on the evaluation of video frames recorded from alveolar microscopy in an experimental setting. Our method includes the recording with a microscopic endoscope, feature extraction from image data, the analysis of a single frame, the tracking and analysis of single alveoli in a video sequence, and the evaluation of the obtained sequence of alveolar geometry data. Our method enables automated analysis of 2-D alveolar geometry with sufficient temporal resolution to follow intratidal dynamics. The developed method and the reproducibility of the results were successfully validated with manually segmented video frames.
影响因子：
8.8
作者：
PARKER, JC;HERNANDEZ, LA;PEEVY, KJ
通讯作者：
PEEVY, KJ