Ring-Opening Metathesis Polymerization in Aqueous Media Using a Macroinitiator Approach
Ring-Opening Metathesis Polymerization in Aqueous Media Using a Macroinitiator Approach
复制标题
使用大分子引发剂方法在水介质中进行开环复分解聚合
DOI：
10.1002/ange.201806719
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发表时间：
2018
影响因子：
--
通讯作者：
Foster J
中科院分区：
文献类型：
--
作者：
Foster J
水溶性和两亲性聚合物引起了工业界和学术界的极大兴趣，因为它们可用于生物材料和药物输送等应用。虽然开环易位聚合（ROMP）是一种用于合成各种聚合物的快速且官能团耐受的方法，但其用于合成水溶性聚合物的全部潜力尚未实现。为了解决这个问题，我们报告了一个一般的策略，在水环境中使用市售的ROMP催化剂和大分子引发剂的方法合成的嵌段共聚物。这允许在水中制备嵌段共聚物时的优异控制。如果选择第二单体使得其形成水不溶性聚合物，则发生聚合诱导的自组装（比萨），并且可以获得各种自组装纳米物体形态。
Water‐soluble and amphiphilic polymers are of great interest to industry and academia, as they can be used in applications such as biomaterials and drug delivery. Whilst ring‐opening metathesis polymerization (ROMP) is a fast and functional group tolerant methodology for the synthesis of a wide range of polymers, its full potential for the synthesis of water‐soluble polymers has yet to be realized. To address this, we report a general strategy for the synthesis of block copolymers in aqueous milieu using a commercially available ROMP catalyst and a macroinitiator approach. This allows for excellent control in the preparation of block copolymers in water. If the second monomer is chosen such that it forms a water‐insoluble polymer, polymerization‐induced self‐assembly (PISA) occurs and a variety of self‐assembled nano‐object morphologies can be accessed.