EFFECTS OF AGE AND SEX ON BONE-DENSITY IN THE RHESUS-MONKEY
EFFECTS OF AGE AND SEX ON BONE-DENSITY IN THE RHESUS-MONKEY
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DOI：
10.1016/8756-3282(89)90007-0
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发表时间：
1989-01-01
期刊：
影响因子：
4.1
通讯作者：
MANN, DR
中科院分区：
文献类型：
--
作者：
POPE, NS;GOULD, KG;MANN, DR
本研究描述了恒河猴皮质骨和松质骨骨密度的规范性数据。恒河猴肱骨、第三腰椎和第八尾椎的骨密度变化（g/cm 2）因受试者的年龄和性别而存在差异（雄性n = 57;雌性n = 49）。一般来说，骨密度随着年龄的增长而增加，然后在所有测量的骨骼中大约3至4岁时达到平台。在肱骨中，老年女性（> 30岁）的骨密度显著低于4至24岁的女性，而老年男性的骨密度没有降低。在脊椎骨中，在两种性别中都发现了与年龄相关的骨密度降低的证据。这些结果表明，恒河猴显示出与人类相似的骨矿化变化的自然模式。恒河猴和人类之间的生理相似性进一步表明该物种在未来骨质疏松症研究中的潜在作用。
Normative data for bone density of cortical and trabecular bone in the rhesus monkeys is described in the present study. Changes of bone density (g/cm2) for the humerus, the third lumbar vertebra, and the eighth caudal vertebra of the rhesus monkey show differences due to age and sex of the subjects (males n = 57; females n = 49). In general, bone density increased with age and then reached a plateau at approximately 3 to 4 years in all bones measured. In the humerus, older females (> 30 years) had a significantly lower bone density than females of 4 to 24 years, while bone density in older males did not decrease. In the vertebrae, some evidence of advanced age-related decreases in bone density was found in both sexes. These results indicate that the rhesus monkey shows a natural pattern of change in bone mineralization which parallels that seen in humans. The physiological similarity between the rhesus monkey and human further suggests a potential role for this species in the future investigation of osteoporosis.