Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder.
Transcutaneous Vagus Nerve Stimulation Modulates Default Mode Network in Major Depressive Disorder.
复制标题
经皮迷走神经刺激调节重度抑郁症的默认模式网络
DOI：
10.1016/j.biopsych.2015.03.025
复制
发表时间：
2016-02-15
影响因子：
10.6
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Fang J;Rong P;Hong Y;Fan Y;Liu J;Wang H;Zhang G;Chen X;Shi S;Wang L;Liu R;Hwang J;Li Z;Tao J;Wang Y;Zhu B;Kong J
Depression is the most common form of mental disorder in community and health care settings and current treatments are far from satisfactory. Vagus nerve stimulation (VNS) is an FDA-approved somatic treatment for treatment-resistant depression. However, the involvement of surgery has limited VNS only to patients who have failed to respond to multiple treatment options. Transcutaneous VNS (tVNS) is a relatively new, non-invasive VNS method based on the rationale that there is afferent / efferent vagus nerve distribution on the surface of the ear. The safe and low-cost characteristics of tVNS have the potential to significantly expand the clinical application of VNS. In this study, we investigated how tVNS can modulate the default mode network (DMN) functional connectivity (FC) in mild or moderate major depressive disorder (MDD) patients. Forty-nine MDD patients were recruited, and received tVNS or sham tVNS (stVNS) treatments. 34 patients completed the study and were included in data analysis. After one month of tVNS treatment, the 24-item Hamilton Depression Rating Scale (HAMD) score reduced significantly in the tVNS group as compared to the stVNS group. The FC between the DMN and anterior insula and parahippocampus decreased; the FC between the DMN and precuneus and orbital prefrontal cortex increased compared to stVNS. All these FC increases are also associated with HAMD reduction. tVNS can significantly modulate the DMN FC of MDD patients; our results provide insights to elucidate the brain mechanism of tVNS treatment for MDD patients.
