Metagenomics and development of the gut microbiota in infants.
Metagenomics and development of the gut microbiota in infants.
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婴儿肠道微生物群的宏基因组学和发育。
DOI：
10.1111/j.1469-0691.2012.03876.x
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Francino,MP
中科院分区：
文献类型：
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作者：
Valles,Y;Gosalbes,MJ;deVries,LE;Abellan,JJ;Francino,MP
临床微生物感染2012；18(补充4)：21-26摘要建立平衡的肠道微生物区系对人类健康的许多方面都是必不可少的，但婴儿胃肠道的微生物定植在个体之间既复杂又高度不同。此外，胃肠道微生物区系经常暴露在抗生素下，可能是婴儿早期耐药菌株和可转移耐药基因的重要储存库。我们正在通过不同的元基因组方法调查婴儿微生物区系发展的几个领域，包括在社区水平上的功能部署、抗生素耐药性的存在以及最丰富的属的种群动态。
Clin Microbiol Infect2012;18(Suppl. 4): 21–26AbstractThe establishment of a balanced intestinal microbiota is essential for numerous aspects of human health, yet the microbial colonization of the gastrointestinal tract of infants is both complex and highly variable among individuals. In addition, the gastrointestinal tract microbiota is often exposed to antibiotics, and may be an important reservoir of resistant strains and of transferable resistance genes from early infancy. We are investigating by means of diverse metagenomic approaches several areas of microbiota development in infants, including the deployment of functional capabilities at the community level, the presence of antibiotic resistances and the population dynamics of the most abundant genera.