Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk
Associations of parental occupational exposure to extremely low-frequency magnetic fields with childhood leukemia risk
复制标题
DOI：
10.3109/10428194.2016.1165812
复制
发表时间：
2016-04
影响因子：
2.6
通讯作者：
Liling Su;Yue Fei;Xiaoxia Wei;Jing Guo;X. Jiang;Liqin Lu;Guangdi Chen
中科院分区：
文献类型：
--
作者：
Liling Su;Yue Fei;Xiaoxia Wei;Jing Guo;X. Jiang;Liqin Lu;Guangdi Chen
以往关于父母职业暴露于极低频磁场（ELF-MF）与儿童白血病风险之间关系的研究得出了不一致的结果。为了重新评估这种关联，我们对11项病例对照研究和1项队列研究进行了荟萃分析。总体结果显示，母亲或父亲的职业暴露与儿童白血病风险无关。对于父亲职业暴露，当合并少量病例（OR =1.96; 95% CI, 1.03-3.74）或较低质量评分（OR =1.52; 95% CI, 1.07-2.15）的研究时，发现显著关联。然而，当汇集大量病例或高质量评分的研究时，这种关联并未得到证实。综上所述，我们的数据表明，父母职业ELF-MF暴露与儿童白血病风险之间没有关联，某些亚组分析中OR升高可能是偶然的。建议进一步开展精确的低频-中频暴露评估研究。
Abstract Previous studies on the association of parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) with childhood leukemia risk have produced inconsistent results. To reevaluate this association, we performed a meta-analysis by pooling 11 case-control and one cohort studies. The overall results showed that neither maternal nor paternal occupational exposure was associated with childhood leukemia risk. For paternal occupational exposure, significant association was found when pooling studies with small number of cases (OR =1.96; 95% CI, 1.03–3.74) or with lower quality score (OR =1.52; 95% CI, 1.07–2.15). However, this association was not confirmed when pooling studies with large number of cases or high quality score. In conclusion, our data indicate no association between parental occupational ELF-MF exposure and childhood leukemia risk, and the elevated OR under certain subgroup analysis is likely due to chance. Further studies with precise ELF-MF exposure assessment are suggested.