Blockade of the locomotor stimulant effects of amphetamine by group I, group II, and group III metabotropic glutamate receptor ligands in the rat nucleus accumbens: possible interactions with dopamine receptors
Blockade of the locomotor stimulant effects of amphetamine by group I, group II, and group III metabotropic glutamate receptor ligands in the rat nucleus accumbens: possible interactions with dopamine receptors
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DOI：
10.1016/s0028-3908(03)00052-2
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发表时间：
2003-05-01
影响因子：
4.7
通讯作者：
Abraini, JH
中科院分区：
文献类型：
--
作者：
David, HN;Abraini, JH
先前的研究表明，mGlu受体可能参与了苯丙胺诱导的运动反应。然而，在方法学方案不同的研究中，数据存在一定的争议。本研究的目的是确定NAcc中mGlu受体参与安非他明对其实验环境习服的大鼠的运动激活特性，这种情况已知调节对安非他明的运动反应。局灶性输注I组mGlu受体拮抗剂S-4-cpg对基础运动活动无影响，实质上抑制苯丙胺的运动反应，而输注II组mGlu受体拮抗剂LY 341495或组III mGlu受体激动剂AP4，在产生运动激活的最小剂量下，使其减少约一半。这些作用分别被组I mGlu受体激动剂DHPG、组11 mGlu受体激动剂APDC和组III mGlu受体拮抗剂MPPG阻断。这些数据证实了NAcc中的mGlu受体参与了苯丙胺的精神刺激运动效应。这些结果是从最近的神经药理学研究的观点来讨论的，这些研究确定了这些mGlu受体配体对暴露于类似实验程序的大鼠的基础运动活动和DA受体激动剂诱导的运动反应的影响(EUR J NeuroScience 13(2001)2157；NeuroPharmology 41(2001)454；EUR J NeuroScience 13(2001)869)。提示mGlu受体在苯丙胺诱发的运动反应中的作用可能主要来源于它们与NAcc中的D1样受体的直接或间接的功能性相互作用。(C)2003爱思唯尔科学有限公司。保留所有权利。
Previous investigations have shown that mGlu receptors would be involved in the amphetamine-induced motor response. However, data are somewhat controversial across studies where methodological protocols vary. The aim of the present study was to determine the involvement of mGlu receptors in the NAcc in the locomotor-activating properties of amphetamine in rats well habituated to their experimental environment, a condition known to modulate the motor response to amphetamine. Focal infusion of the group I mGlu receptor antagonist S-4-CPG, which has no effect on basal motor activity, virtually suppressed the locomotor response to amphetamine, while infusion of the group II mGlu receptor antagonist LY 341495 or the group III mGlu receptor agonist AP4, at the minimal dose that produces locomotor activation, reduced it by approximately a half. These effects were blocked by the group I mGlu receptor agonist DHPG, the group 11 mGlu receptor agonist APDC, and the group III mGlu receptor antagonist MPPG, respectively. These data confirm that mGlu receptors in the NAcc contribute to the psychostimulant motor effect of amphetamine. Results are discussed from the view of recent neuropharmacological studies that have defined the effects of these mGlu receptor ligands on basal motor activity and DA receptor agonists-induced locomotor responses in rats exposed to similar experimental procedures (Eur J Neuroscience 13 (2001) 2157; Neuropharmacology 41 (2001) 454; Eur J Neuroscience 13 (2001) 869). It is suggested that the contribution of mGlu receptors to the amphetamine-induced motor response may result mainly from their functional, either direct or indirect, interactions with D1-like receptors in the NAcc. (C) 2003 Elsevier Science Ltd. All rights reserved.