Neural correlates of inhibitory control and visual processing in youths with attention deficit hyperactivity disorder: a counting Stroop functional MRI study
Neural correlates of inhibitory control and visual processing in youths with attention deficit hyperactivity disorder: a counting Stroop functional MRI study
复制标题
DOI：
10.1017/s0033291714000038
复制
发表时间：
2014-09-01
影响因子：
6.9
通讯作者：
Chou, T. -L.
中科院分区：
文献类型：
--
作者：
Fan, L. -Y.;Gau, S. S. -F.;Chou, T. -L.
背景。尽管有证据表明注意力缺陷多动障碍（ADHD）存在抑制控制和视觉处理障碍，但有关大脑中相应变化的知识仍在不断发展。目前的研究使用计数斯特鲁普功能性 MRI 和剑桥神经心理学测试自动电池 (CANTAB) 来调查患有 ADHD 的青少年的抑制控制和视觉处理的大脑激活是否与神经典型的青少年不同。我们评估了 25 名患有 ADHD 的青少年 [平均年龄 10.9 (S.D.=2.2) 岁] 和 23 名年龄、性别和智商匹配的神经典型青少年 [平均年龄 11.2 (S.D.=2.9) 岁]。参与者使用韦克斯勒儿童智力量表第三版和 CANTAB 的两项测试进行评估：快速视觉信息处理（RVP）和扫描仪外的模式识别记忆（PRM）。结果。患有 ADHD 的青少年的右额下回 [布罗德曼区 (BA) 45] 和前扣带皮层比神经正常青少年表现出更多的激活，这与 CANTAB 中 RVP 测试的较差表现相关。相比之下，患有 ADHD 的青少年左上顶小叶 (BA 5/7) 的激活程度低于神经正常青少年，这与 CANTAB 中 PRM 测试的正确反应百分比相关。结论。我们的研究结果表明，与神经正常的青少年相比，患有多动症的青少年可能需要更多的抑制控制来抑制数字和意义之间的干扰，并且可能需要更少的视觉处理来处理计算斯特鲁普任务中的数字。
Background. Despite evidence of inhibitory control and visual processing impairment in attention deficit hyperactivity disorder (ADHD), knowledge about its corresponding alterations in the brain is still evolving. The current study used counting Stroop functional MRI and the Cambridge Neuropsychological Test Automated Battery (CANTAB) to investigate if brain activation of inhibitory control and visual processing would differ in youths with ADHD relative to neuro-typical youths.Method. We assessed 25 youths with ADHD [mean age 10.9 (S.D.=2.2) years] and 23 age-, gender-and IQ-matched neurotypical youths [mean age 11.2 (S.D.=2.9) years]. The participants were assessed by using the Wechsler Intelligence Scale for Children, third edition, and two tests from the CANTAB: rapid visual information processing (RVP) and pattern recognition memory (PRM) outside the scanner.Results. Youths with ADHD showed more activation than neurotypical youths in the right inferior frontal gyrus [Brodmann area (BA) 45] and anterior cingulate cortex, which were correlated with poorer performance on the RVP test in the CANTAB. In contrast, youths with ADHD showed less activation than neurotypical youths in the left superior parietal lobule (BA 5/7), which was correlated with the percentage of correct responses on the PRM test in the CANTAB.Conclusions. Our findings suggest that youths with ADHD might need more inhibitory control to suppress interference between number and meaning and may involve less visual processing to process the numbers in the counting Stroop task than neurotypical youths.