Rheumatoid arthritis: CCN1, a novel RA target?
Rheumatoid arthritis: CCN1, a novel RA target?
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DOI：
10.1038/nrrheum.2016.138
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发表时间：
2016-10-01
期刊：
影响因子：
--
通讯作者：
Barranco, Caroline
中科院分区：
文献类型：
--
作者：
Barranco, Caroline
根据台湾研究人员发表的最新证据，蛋白CYR61(富含半胱氨酸的血管生成诱导物61，又称CCN1)是类风湿关节炎(RA)中一种重要的促炎细胞因子。他们发现类风湿性关节炎患者的滑液中CCN1水平升高，并表明在类风湿关节炎模型--胶原性关节炎小鼠中，敲除CCN1(使用慢病毒载体传递的短发夹状RNA)抑制关节肿胀和软骨侵蚀。有趣的是，CCN1的敲除也阻止了成骨细胞产生血管内皮生长因子(VEGF)，导致血管新生抑制和血管生成标记物的表达减少。唐志新强调：我们的工作还证明了成骨细胞和类风湿关节炎血管生成之间的联系。我们提供的证据表明，在RA期间，成骨细胞产生血管内皮生长因子，促进内皮祖细胞(EPC)在关节微环境中的渗透和血管生成。
Protein CYR61 (cysteine-rich angiogenic inducer 61, also known as CCN1) is an important proinflammatory cytokine in rheumatoid arthritis (RA), according to new evidence published by Taiwanese researchers. They found elevated levels of CCN1 in synovial fluid from patients with RA, and showed that in mice with collagen-induced arthritis, a model of RA, knockdown of CCN1 (using a short hairpin RNA delivered by a lentiviral vector) suppressed joint swelling and cartilage erosion.Interestingly, knockdown of CCN1 also blocked the production of vascular endothelial growth factor (VEGF) by osteoblasts, leading to suppression of pannus neovascularization and decreased expression of angiogenesis markers.“Our work also demonstrates a link between osteoblasts and angiogenesis in RA,” highlights Chih-Hsin Tang, corresponding author of the study.“We provide evidence showing that osteoblasts produce VEGF and promote endothelial progenitor cell (EPC) infiltration and angiogenesis in the joint microenvironment during RA,” he explains.