Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases.
Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases.
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DOI：
10.3389/fgene.2020.590369
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发表时间：
2020
影响因子：
3.7
通讯作者：
Kim KH
中科院分区：
文献类型：
--
作者：
Asif S;Morrow NM;Mulvihill EE;Kim KH
肥胖、糖尿病和脂肪肝等代谢紊乱的全球患病率正在急剧增加。遗传和环境因素都是这些疾病发展的众所周知的贡献者，因此，表观遗传学的研究可以提供额外的机制见解。饮食干预，包括热量限制、间歇性禁食或限时喂养，已显示出患者总体代谢谱的有希望改善（即，减轻体重，改善葡萄糖稳态），并且越来越多的研究将这些有益作用与表观遗传改变相关联。在这篇文章中，我们回顾了在主要代谢组织（即，脂肪、肝脏和胰腺），希望阐明用于疾病预防和治疗的潜在生物标志物和治疗靶点。
The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver disease, is dramatically increasing. Both genetic and environmental factors are well-known contributors to the development of these diseases and therefore, the study of epigenetics can provide additional mechanistic insight. Dietary interventions, including caloric restriction, intermittent fasting or time-restricted feeding, have shown promising improvements in patients’ overall metabolic profiles (i.e., reduced body weight, improved glucose homeostasis), and an increasing number of studies have associated these beneficial effects with epigenetic alterations. In this article, we review epigenetic changes involved in both metabolic diseases and dietary interventions in primary metabolic tissues (i.e., adipose, liver, and pancreas) in hopes of elucidating potential biomarkers and therapeutic targets for disease prevention and treatment.
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