Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo
Attenuation of paraquat-induced motor behavior and neurochemical disturbances by L-valine in vivo
复制标题
DOI：
10.1016/j.toxlet.2004.02.007
复制
发表时间：
2004-05-02
影响因子：
3.5
通讯作者：
Satayavivad, J
中科院分区：
文献类型：
--
作者：
Chanyachukul, T;Yoovathaworn, K;Satayavivad, J
研究了急性百草枯暴露（3、5、10、20 mg/kg，皮下注射）后大鼠大脑离散区域运动行为模式和单胺含量的变化。结果表明，5、10 和 20 mg/kg 剂量的百草枯可显着降低运动、定型和旋转行为。检测到皮质和下丘脑去甲肾上腺素（NE）含量以及纹状体多巴胺（DA）及其酸性代谢物含量显着降低。此外，L-缬氨酸（200 mg/kg，腹腔注射）在中等剂量（5 mg/kg）时可显着减弱百草枯引起的毒性，但在高剂量（20 mg/kg）时则不能。结果证明百草枯可以进入大脑，运动行为模式和神经化学物质含量的改变就表明了这一点。此外，检测到L-缬氨酸对全身施用百草枯诱导的运动行为具有减弱作用，对百草枯诱导的神经化学改变具有轻微的保护作用。 (C) 2004 Elsevier Ireland Ltd. 保留所有权利。
Alterations of motor behavioral patterns and monoamine contents in the discrete rat brain areas after acute paraquat exposure (3, 5, 10, 20 mg/kg, s.c.) have been studied. The results showed that paraquat at the doses of 5, 10, and 20 mg/kg significantly reduced locomotive, stereotypic, and rotational behaviors. Significant decreases of norepinephrine (NE) contents in cortex and hypothalamus, as well as striatal contents of dopamine (DA) and its acidic metabolites, were detected. In addition, L-valine (200 mg/kg, i.p.) significantly attenuated paraquat-induced toxicity at moderate dose (5 mg/kg) but not at high dose (20 mg/kg). The results provide evidence that paraquat can enter the brain as illustrated by the alterations in the motor behavioral pattern and neurochemical contents. Furthermore, the attenuation effect Of L-valine against systemic administration of paraquat-induced motor behaviors was detected, with a slightly protective effect on paraquat-induced neurochemical alterations. (C) 2004 Elsevier Ireland Ltd. All rights reserved.