Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria
Diagnosis of antiretroviral therapy failure in Malawi: poor performance of clinical and immunological WHO criteria
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DOI：
10.1111/j.1365-3156.2009.02309.x
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发表时间：
2009-08-01
影响因子：
3.3
通讯作者：
Hosseinipour, Mina C.
中科院分区：
文献类型：
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作者：
van Oosterhout, Joep J. G.;Brown, Lillian;Hosseinipour, Mina C.
在撒哈拉以南非洲的抗逆转录病毒治疗（ART）扩大规划中，不建议进行病毒载量监测。我们想研究常规情况下仅使用临床和免疫监测对ART病毒学失败诊断的影响。方法马拉维两家城市抗逆转录病毒治疗诊所的临床医生通过临床和免疫监测来确定是否改用二线抗逆转录病毒治疗的成年患者。如果患者符合世卫组织指南的临床和/或免疫失败标准，并且有病毒载量
OBJECTIVES In antiretroviral therapy (ART) scale-up programmes in sub-Saharan Africa viral load monitoring is not recommended. We wanted to study the impact of only using clinical and immunological monitoring on the diagnosis of virological ART failure under routine circumstances. methods Clinicians in two urban ART clinics in Malawi used clinical and immunological monitoring to identify adult patients for switching to second-line ART. If patients met clinical and/or immunological failure criteria of WHO guidelines and had a viral load