Absence of competitive interactions among axon terminals of regenerating motor neurons.
Absence of competitive interactions among axon terminals of regenerating motor neurons.
复制标题
再生运动神经元的轴突末端之间缺乏竞争性相互作用。
DOI：
10.1002/neu.480190707
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
MurphyJr,BF
中科院分区：
文献类型：
--
作者：
Denburg,JL;Powell,SL;MurphyJr,BF
轴突终末之间的竞争通常被认为有助于形成模式化的突触连接。在蟑螂运动神经元轴突再生过程中，腿部肌肉最初由适当和不适当的运动神经元支配。所有来自不适当神经元的轴突终末最终被清除，导致原始神经支配模式的重建。通过胞内注射链霉蛋白酶破坏一个确定的运动神经元，并不能阻止正常受该运动神经元支配的肌肉中不适当的轴突终末的延伸。因此，比赛在腿部肌肉的神经再支配中不起作用。这表明特异性细胞-细胞识别的主要作用。
Competition among axon terminals is usually considered to contribute to the formation of patterned synaptic connections. During axonal regeneration of motor neurons in the cockroach, leg muscles initially become innervated by appropriate and inappropriate motor neurons. All axon terminals from inappropriate neurons eventually are eliminated, resulting in the reformation of the original innervation pattern. Destruction of an identified motor neuron by the intracellular injection of pronase did not prevent the eilimenation of inappropriate axon terminals in the muscle normally innervated by that motor neuron. Therefore, competition does not play a role in the reinnervation of the leg muscles. This indicates a major role for specific cell‐cell recognition.