Transporter‐Mediated Drug–Drug Interactions
Transporter‐Mediated Drug–Drug Interactions
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DOI：
10.1038/clpt.2010.359
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发表时间：
2011-04
影响因子：
6.7
通讯作者：
Lei Zhang;Shiew-Mei Huang;L. Lesko
中科院分区：
文献类型：
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作者：
Lei Zhang;Shiew-Mei Huang;L. Lesko
转运蛋白是膜结合蛋白，控制内源性和外源性物质（药物）进入人体的各个部位。它们通过影响药物的吸收、分布、代谢（通过控制代谢酶的进入）和排泄（ADME）以及通过控制作用部位的药物浓度来影响药物的药代动力学和药效学（获益和风险）。像代谢酶一样，转运蛋白具有可饱和的结合位点，并且可以被抑制或诱导.Clinical Pharmacology & Therapeutics（2011）894，481-484. doi：10.1038/clpt.2010.359
Transporters are membrane‐bound proteins that control the access of endogenous and xenobiotics (drugs) to various sites in the human body. They influence drug pharmacokinetics and pharmacodynamics (both benefit and risk) by affecting a drug's absorption, distribution, metabolism (via control of access to metabolizing enzymes), and excretion (ADME) and by controlling drug concentrations at the site of action. Like metabolizing enzymes, transporters have binding sites that are saturable and can be inhibited or induced.Clinical Pharmacology & Therapeutics(2011)894, 481–484. doi:10.1038/clpt.2010.359