Regional differences of cFos immunoreactive cells in the preoptic areas in hypothalamus associated with heat and cold responses in mice
Regional differences of cFos immunoreactive cells in the preoptic areas in hypothalamus associated with heat and cold responses in mice
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DOI：
10.1016/j.neulet.2017.11.053
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发表时间：
2018-02-05
影响因子：
2.5
通讯作者：
Nagashima，Kei
中科院分区：
文献类型：
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作者：
Uchida，Yuki;Onishi，Keisuke;Nagashima，Kei
冷热暴露均增加视前区（PO）中cFos的表达；然而，地区差异尚不清楚。我们的目的是确定cFos在PO中的表达在冷热暴露中是否存在区域差异。小鼠分别暴露于27、10或38°C环境90分钟，测量体温（Tb）。通过将PO分成吻侧（0.38 mm）、中央（- 0.10 mm）和尾侧（- 0.46 mm）平面的腹侧和背侧来计数PO中的cfos免疫反应细胞（cFos-IR）。10°C保持不变；然而，在38°C时，它增加了。38°C时各部位cFos-IR细胞计数均大于27°C时。在中央和尾部PO的背侧和腹侧，cFos-IR细胞计数在10°C时高于27°C。综上所述，小鼠PO中cFos在高温条件下表达增加的区域与低温条件下不同。
cFos expression in the preoptic area (PO), which is thermoregulatory center increased by both heat and cold exposures; however, the regional difference is unknown yet. We aimed to determine if cFos expression in the PO was regionally different between heat and cold exposures. Mice were exposed to 27, 10, or 38 °C for 90 min, and body temperature (Tb) was measured. cFos-immunoreactive (cFos-IR) cells in the PO were counted by separating the PO into the ventral and dorsal parts in the rostral (bregma 0.38 mm), central (−0.10 mm), and caudal (−0.46 mm) planes. Tbat 10 °C remained unchanged; however, it increased at 38 °C. Counts of cFos-IR cells in all areas were greater at 38 °C than at 27 °C. In the dorsal and ventral parts of the central and the dorsal part of caudal PO, counts of cFos-IR cells were greater at 10 °C than at 27 °C. In conclusion, the areas of increased cFos expression in the PO in the heat were different that in the cold in mice.