Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
Preparation and In Vitro Behavior of a Poly(lactic acid)-Fiber/Hydroxyapatite Composite Sheet
复制标题
DOI：
10.1155/2009/827241
复制
发表时间：
2009
影响因子：
--
通讯作者：
Y. Tanimoto;N. Nishiyama
中科院分区：
文献类型：
--
作者：
Y. Tanimoto;N. Nishiyama
本文介绍了一种用于骨组织工程的聚乳酸（PLA）纤维/羟基磷灰石（HA）复合材料的制备工艺和体外性能。使用I型胶原蛋白作为粘合剂，将PLA纤维和HA粉末联合收割机。监测Hanks平衡盐（HBS）溶液中磷灰石的形成以评价PLA纤维/HA复合片材的体外磷灰石形成能力。在PLA-纤维/HA复合材料片材的表面上在浸入HBS溶液仅1天后观察到沉淀物形成，而在作为对照的没有HA的PLA-纤维片材上没有观察到沉淀物形成。综上所述，成功制备了用作支架的PLA纤维/HA复合片材。在本研究的限制范围内，我们证实了PLA-纤维/HA复合片材与PLA-纤维片材相比具有高的磷灰石形成活性，并且代表了用作支架的有前景的材料。
This paper describes the processing and in vitro behavior of a poly(lactic acid) (PLA)-fiber/hydroxyapatite (HA) composite sheet consisting of a knitted PLA-fiber sheet and HA powder for bone tissue engineering. Type I collagen was used as a binding agent to combine the PLA fibers and the HA powder. Precipitate formation in Hanks' balanced salt (HBS) solution was monitored to evaluate the in vitro apatite formation ability of the PLA-fiber/HA composite sheet. Precipitate formation was observed on the surface of the PLA-fiber/HA composite sheet after immersion in HBS solution for only 1 day, while no precipitate formation was observed on the PLA-fiber sheet without HA as a control. In conclusion, a PLA-fiber/HA composite sheet for use as a scaffold was successfully prepared. Within the limitations of this investigation, we confirmed that the PLA-fiber/HA composite sheet has a high apatite formation activity compared with the PLA-fiber sheet and represents a promising material for use as a scaffold.