ANTIGENS OF BORRELIA-BURGDORFERI RECOGNIZED DURING LYME-DISEASE - APPEARANCE OF A NEW IMMUNOGLOBULIN-M RESPONSE AND EXPANSION OF THE IMMUNOGLOBULIN-G RESPONSE LATE IN THE ILLNESS
ANTIGENS OF BORRELIA-BURGDORFERI RECOGNIZED DURING LYME-DISEASE - APPEARANCE OF A NEW IMMUNOGLOBULIN-M RESPONSE AND EXPANSION OF THE IMMUNOGLOBULIN-G RESPONSE LATE IN THE ILLNESS
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DOI：
10.1172/jci112683
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发表时间：
1986-10-01
影响因子：
15.9
通讯作者：
STEERE, AC
中科院分区：
文献类型：
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作者：
CRAFT, JE;FISCHER, DK;STEERE, AC
使用免疫印迹，我们鉴定了莱姆病期间与 IgM 和 IgG 抗体结合的伯氏疏螺旋体的蛋白质。在 12 名患有早期疾病的患者中，IgM 和 IgG 反应均主要局限于 41-kD 抗原。这种有限的反应在几个月内就消失了。相比之下，在六名长期患病的患者中，对 41-kD 蛋白质的 IgM 反应有时会持续数月至数年，并且在关节炎期间的疾病晚期，有时会对生物体的 34-kD 成分产生新的 IgM 反应。这些患者的 IgG 反应在数月至数年内以特征性的连续模式出现，对多达 11 种螺旋体抗原产生反应。在疾病后期出现新的 IgM 反应和 IgG 反应的扩大，以及仅早期疾病患者缺乏此类反应，表明伯氏疏螺旋体在整个疾病过程中仍然存活。
Using immunoblots, we identified proteins of Borrelia burgdorferi bound by IgM and IgG antibodies during Lyme disease. In 12 patients with early disease alone, both the IgM and IgG responses were restricted primarily to a 41-kD antigen. This limited response disappeared within several months. In contrast, among six patients with prolonged illness, the IgM response to the 41-kD protein sometimes persisted for months to years, and late in the illness during arthritis, a new IgM response sometimes developed to a 34-kD component of the organism. The IgG response in these patients appeared in a characteristic sequential pattern over months to years to as many as 11 spirochetal antigens. The appearance of a new IgM response and the expansion of the IgG response late in the illness, and the lack of such responses in patients with early disease alone, suggest that B. burgdorferi remains alive throughout the illness.