Targeting Nitric Oxide: Say NO to Metastasis.
Targeting Nitric Oxide: Say NO to Metastasis.
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DOI：
10.1158/1078-0432.ccr-22-2791
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发表时间：
2023-05-15
影响因子：
11.5
通讯作者：
Chang, Jenny C.
中科院分区：
文献类型：
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作者：
Reddy, Tejaswini P.;Glynn, Sharon A.;Billiar, Timothy R.;Wink, David A.;Chang, Jenny C.
利用能够减少癌症转移、靶向耐药和自我更新的癌症干细胞以及增强全身化疗/放疗疗效的靶向治疗对于最大限度地降低癌症相关死亡率至关重要。靶向一氧化氮合酶（NOS），肿瘤微环境中的蛋白质，已经获得了兴趣，作为一个有前途的治疗策略，以减少转移能力和增强各种实体恶性肿瘤的化疗/放疗的疗效。我们的综述强调了一氧化氮（NO）在肿瘤进展和癌症转移中的影响，以及评估NOS抑制剂作为抗癌疗法的有前途的临床前研究。最后，我们强调了在临床环境中使用NOS抑制剂的前景和突出的挑战。
Utilizing targeted therapies capable of reducing cancer metastasis, targeting chemoresistant and self-renewing cancer stem cells, and augmenting the efficacy of systemic chemo/radiotherapies is vital to minimize cancer-associated mortality. Targeting nitric oxide synthase (NOS), a protein within the tumor microenvironment, has gained interest as a promising therapeutic strategy to reduce metastatic capacity and augment the efficacy of chemo/radiotherapies in various solid malignancies. Our review highlights the influence of nitric oxide (NO) in tumor progression and cancer metastasis, as well as promising preclinical studies that evaluated NOS inhibitors as anticancer therapies. Lastly, we highlight the prospects and outstanding challenges of using NOS inhibitors in the clinical setting.
诱导型一氧化氮合酶基因转染可抑制 K-1735 鼠黑色素瘤细胞的致瘤性并消除转移。
影响因子：
15.3
作者：
Xie, Keping;Huang, Suyun;Dong, Zhongyun;Juang, Shin-Hun;Gutman, Mordechai;Xie, Qiao-Wen;Nathan, Carl;Fidler, Isaiah J.
通讯作者：
Fidler, Isaiah J.