Extracellular vesicles in renal tissue damage and regeneration
Extracellular vesicles in renal tissue damage and regeneration
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DOI：
10.1016/j.ejphar.2016.06.058
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发表时间：
2016-11-05
影响因子：
5
通讯作者：
Bussolati, Benedetta
中科院分区：
文献类型：
--
作者：
Bruno, Stefania;Porta, Stefano;Bussolati, Benedetta
细胞外小泡(EV)在细胞间的通讯中扮演着重要角色。EV含量的特征是动态反映细胞和组织状态的蛋白质和RNA种类。尤其是尿液中的EVS可能起到肾单位间通讯的作用，可能有益，也可能有害。作为一种无细胞疗法，EVS的药理学特性引起了越来越多的兴趣，因为对干细胞编辑的crAQ/tgqc的几种作用已通过给药来概括。肾损伤模型的临床前数据表明，来自不同来源的间充质基质细胞的EV具有普遍的再生潜力，包括骨髓、胎儿组织、尿液和肾脏。本文就EVS在急慢性肾损伤修复中的作用及其机制的研究进展作一综述。此外，我们还将分析EV在肾脏再生医学中的药理应用策略以及所涉及的局限性和好处。(C)2016年提交人。爱思唯尔出版公司(Elsevier B.V.)
Extracellular vesicles (EVs) appear as important actors in cell-to-cell communication. EV content is characterized by proteins and RNA species that dynamically reflect cell and tissue state. Urinary EVs in particular may act in inter-nephron communication with possible beneficial or detrimental effects. Increasing interest is addressed to the pharmacological properties of EVs as a cell-free therapy, since several of the effects crAQ/tgqcedited to stem cells have been recapitulated by administration of their EVs. Preclinical data in models of renal damage indicate a general regenerative potential of EVs derived from mesenchymal stromal cells of different sources, including bone marrow, fetal tissues, urine and kidney. In this review we will discuss the results on the effect of EVs in repair of acute and chronic renal injury, and the mechanisms involved. In addition, we will analyse the strategies for EV pharmacological applications in renal regenerative medicine and limits and benefits involved. (C) 2016 The Authors. Published by Elsevier B.V.